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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SPTLC1
All Species:
2.12
Human Site:
T93
Identified Species:
3.33
UniProt:
O15269
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15269
NP_006406.1
473
52744
T93
S
G
P
P
S
H
K
T
V
V
N
G
K
E
C
Chimpanzee
Pan troglodytes
XP_520127
343
38184
E29
L
A
K
F
M
K
T
E
E
A
I
I
Y
S
Y
Rhesus Macaque
Macaca mulatta
XP_001102219
486
54533
I93
S
G
P
P
S
H
K
I
V
V
N
G
K
E
C
Dog
Lupus familis
XP_541308
473
52782
I93
S
G
P
P
S
H
N
I
V
V
N
G
K
K
C
Cat
Felis silvestris
Mouse
Mus musculus
O35704
473
52472
I93
S
G
P
P
T
H
N
I
V
V
N
G
K
E
C
Rat
Rattus norvegicus
NP_001101876
473
52530
I93
S
G
P
P
T
H
N
I
V
V
N
G
K
E
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_423815
576
63994
I196
S
G
P
P
T
H
K
I
I
V
N
G
K
E
C
Frog
Xenopus laevis
NP_001084963
472
53096
I92
S
G
P
P
S
H
K
I
V
V
N
G
K
E
C
Zebra Danio
Brachydanio rerio
NP_001018307
472
53307
I92
T
G
P
P
S
H
K
I
I
V
N
G
K
E
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_610842
468
52515
I89
Q
S
R
V
G
K
R
I
Q
V
D
G
H
D
C
Honey Bee
Apis mellifera
XP_624768
467
52785
I88
T
S
R
A
G
K
R
I
V
V
D
G
K
D
C
Nematode Worm
Caenorhab. elegans
NP_001021978
458
52066
V81
D
G
K
M
T
K
D
V
S
I
D
G
E
K
Y
Sea Urchin
Strong. purpuratus
XP_001178756
460
51271
V76
Q
G
N
N
K
L
V
V
D
G
K
E
G
I
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001147940
485
52439
T106
E
S
A
A
G
P
H
T
I
V
D
G
K
E
V
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P25045
558
62189
N138
N
H
I
T
I
T
R
N
N
L
Q
E
K
Y
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
71.6
77.7
94.9
N.A.
91.7
91.3
N.A.
N.A.
71.1
86.8
84.1
N.A.
49.6
46.5
47.7
54.1
Protein Similarity:
100
72
80.8
98.3
N.A.
96.6
96.6
N.A.
N.A.
77
92.1
91.5
N.A.
67.8
68.7
66.5
73.5
P-Site Identity:
100
0
93.3
80
N.A.
80
80
N.A.
N.A.
80
93.3
80
N.A.
20
33.3
13.3
6.6
P-Site Similarity:
100
0
93.3
86.6
N.A.
86.6
86.6
N.A.
N.A.
93.3
93.3
93.3
N.A.
40
60
46.6
6.6
Percent
Protein Identity:
N.A.
44.9
N.A.
N.A.
32.6
N.A.
Protein Similarity:
N.A.
63
N.A.
N.A.
48.7
N.A.
P-Site Identity:
N.A.
33.3
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
46.6
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
7
14
0
0
0
0
0
7
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
67
% C
% Asp:
7
0
0
0
0
0
7
0
7
0
27
0
0
14
0
% D
% Glu:
7
0
0
0
0
0
0
7
7
0
0
14
7
54
0
% E
% Phe:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
67
0
0
20
0
0
0
0
7
0
80
7
0
0
% G
% His:
0
7
0
0
0
54
7
0
0
0
0
0
7
0
0
% H
% Ile:
0
0
7
0
7
0
0
60
20
7
7
7
0
7
0
% I
% Lys:
0
0
14
0
7
27
34
0
0
0
7
0
74
14
0
% K
% Leu:
7
0
0
0
0
7
0
0
0
7
0
0
0
0
0
% L
% Met:
0
0
0
7
7
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
7
0
7
7
0
0
20
7
7
0
54
0
0
0
7
% N
% Pro:
0
0
54
54
0
7
0
0
0
0
0
0
0
0
0
% P
% Gln:
14
0
0
0
0
0
0
0
7
0
7
0
0
0
0
% Q
% Arg:
0
0
14
0
0
0
20
0
0
0
0
0
0
0
0
% R
% Ser:
47
20
0
0
34
0
0
0
7
0
0
0
0
7
0
% S
% Thr:
14
0
0
7
27
7
7
14
0
0
0
0
0
0
7
% T
% Val:
0
0
0
7
0
0
7
14
47
74
0
0
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
7
7
14
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _