KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SPTLC1
All Species:
33.94
Human Site:
Y82
Identified Species:
53.33
UniProt:
O15269
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15269
NP_006406.1
473
52744
Y82
K
D
H
P
A
L
N
Y
N
I
V
S
G
P
P
Chimpanzee
Pan troglodytes
XP_520127
343
38184
L18
N
I
D
V
H
L
D
L
E
E
R
L
A
K
F
Rhesus Macaque
Macaca mulatta
XP_001102219
486
54533
Y82
K
D
H
P
A
L
N
Y
N
I
V
S
G
P
P
Dog
Lupus familis
XP_541308
473
52782
Y82
K
D
H
P
A
L
N
Y
N
I
V
S
G
P
P
Cat
Felis silvestris
Mouse
Mus musculus
O35704
473
52472
Y82
K
N
H
P
A
L
N
Y
N
I
V
S
G
P
P
Rat
Rattus norvegicus
NP_001101876
473
52530
Y82
R
N
H
P
A
L
N
Y
N
I
V
S
G
P
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_423815
576
63994
Y185
K
D
H
P
A
L
N
Y
N
I
V
S
G
P
P
Frog
Xenopus laevis
NP_001084963
472
53096
Y81
K
D
H
P
A
L
N
Y
N
I
V
S
G
P
P
Zebra Danio
Brachydanio rerio
NP_001018307
472
53307
Y81
K
D
H
P
S
L
N
Y
D
V
V
T
G
P
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_610842
468
52515
T78
P
N
H
P
L
L
H
T
R
V
V
Q
S
R
V
Honey Bee
Apis mellifera
XP_624768
467
52785
P77
T
N
H
L
S
L
N
P
R
C
I
T
S
R
A
Nematode Worm
Caenorhab. elegans
NP_001021978
458
52066
P70
Q
D
H
P
V
L
N
P
K
Y
A
D
G
K
M
Sea Urchin
Strong. purpuratus
XP_001178756
460
51271
V65
H
P
A
L
H
Y
K
V
I
T
K
Q
G
N
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001147940
485
52439
A95
K
E
G
A
K
I
D
A
P
T
L
E
S
A
A
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P25045
558
62189
M127
K
T
P
V
T
M
E
M
P
I
Q
N
H
I
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
71.6
77.7
94.9
N.A.
91.7
91.3
N.A.
N.A.
71.1
86.8
84.1
N.A.
49.6
46.5
47.7
54.1
Protein Similarity:
100
72
80.8
98.3
N.A.
96.6
96.6
N.A.
N.A.
77
92.1
91.5
N.A.
67.8
68.7
66.5
73.5
P-Site Identity:
100
6.6
100
100
N.A.
93.3
86.6
N.A.
N.A.
100
100
73.3
N.A.
26.6
20
40
6.6
P-Site Similarity:
100
13.3
100
100
N.A.
100
100
N.A.
N.A.
100
100
100
N.A.
46.6
46.6
46.6
6.6
Percent
Protein Identity:
N.A.
44.9
N.A.
N.A.
32.6
N.A.
Protein Similarity:
N.A.
63
N.A.
N.A.
48.7
N.A.
P-Site Identity:
N.A.
6.6
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
33.3
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
7
47
0
0
7
0
0
7
0
7
7
14
% A
% Cys:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% C
% Asp:
0
47
7
0
0
0
14
0
7
0
0
7
0
0
0
% D
% Glu:
0
7
0
0
0
0
7
0
7
7
0
7
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% F
% Gly:
0
0
7
0
0
0
0
0
0
0
0
0
67
0
0
% G
% His:
7
0
74
0
14
0
7
0
0
0
0
0
7
0
0
% H
% Ile:
0
7
0
0
0
7
0
0
7
54
7
0
0
7
0
% I
% Lys:
60
0
0
0
7
0
7
0
7
0
7
0
0
14
0
% K
% Leu:
0
0
0
14
7
80
0
7
0
0
7
7
0
0
0
% L
% Met:
0
0
0
0
0
7
0
7
0
0
0
0
0
0
7
% M
% Asn:
7
27
0
0
0
0
67
0
47
0
0
7
0
7
7
% N
% Pro:
7
7
7
67
0
0
0
14
14
0
0
0
0
54
54
% P
% Gln:
7
0
0
0
0
0
0
0
0
0
7
14
0
0
0
% Q
% Arg:
7
0
0
0
0
0
0
0
14
0
7
0
0
14
0
% R
% Ser:
0
0
0
0
14
0
0
0
0
0
0
47
20
0
0
% S
% Thr:
7
7
0
0
7
0
0
7
0
14
0
14
0
0
7
% T
% Val:
0
0
0
14
7
0
0
7
0
14
60
0
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
7
0
54
0
7
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _