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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SPTLC2
All Species:
43.94
Human Site:
S258
Identified Species:
87.88
UniProt:
O15270
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15270
NP_004854.1
562
62924
S258
G
K
G
C
L
I
L
S
D
E
L
N
H
A
S
Chimpanzee
Pan troglodytes
XP_510095
893
98301
S589
G
K
G
C
L
I
L
S
D
E
L
N
H
A
S
Rhesus Macaque
Macaca mulatta
XP_001096042
780
85448
S362
G
K
G
C
L
I
L
S
D
E
L
N
H
A
S
Dog
Lupus familis
XP_537524
691
75896
S387
G
K
G
C
L
I
L
S
D
E
L
N
H
A
S
Cat
Felis silvestris
Mouse
Mus musculus
P97363
560
62963
S256
G
K
G
C
L
I
L
S
D
E
L
N
H
A
S
Rat
Rattus norvegicus
NP_001032174
560
62943
S256
G
K
G
C
L
I
L
S
D
E
L
N
H
A
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514082
550
62189
S248
G
K
G
C
L
I
L
S
D
E
L
N
H
T
S
Chicken
Gallus gallus
NP_001006483
560
62717
S256
G
K
G
C
L
I
L
S
D
E
L
N
H
A
S
Frog
Xenopus laevis
NP_001085763
555
62268
S251
G
K
G
C
L
I
L
S
D
E
L
N
H
S
S
Zebra Danio
Brachydanio rerio
NP_001018455
534
60425
G241
N
H
A
S
L
V
L
G
A
R
L
S
G
S
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784261
549
60922
S253
G
R
G
C
L
I
V
S
D
R
L
N
H
A
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P40970
561
63092
S245
D
K
K
C
L
V
I
S
D
E
L
N
H
T
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
61.9
68.4
78.8
N.A.
96
95.3
N.A.
70.6
87.5
79.1
76.1
N.A.
N.A.
N.A.
N.A.
58.3
Protein Similarity:
100
62.7
70.5
80.7
N.A.
98.5
98.2
N.A.
82.9
92.5
87.7
86.6
N.A.
N.A.
N.A.
N.A.
73.1
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
93.3
100
93.3
20
N.A.
N.A.
N.A.
N.A.
80
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
93.3
100
100
46.6
N.A.
N.A.
N.A.
N.A.
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
44.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
63.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
66.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
80
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
0
0
0
0
0
9
0
0
0
0
67
0
% A
% Cys:
0
0
0
92
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
0
0
0
0
0
0
0
92
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
84
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
84
0
84
0
0
0
0
9
0
0
0
0
9
0
0
% G
% His:
0
9
0
0
0
0
0
0
0
0
0
0
92
0
0
% H
% Ile:
0
0
0
0
0
84
9
0
0
0
0
0
0
0
0
% I
% Lys:
0
84
9
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
100
0
84
0
0
0
100
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
9
0
0
0
0
0
0
0
0
0
0
92
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
9
0
0
0
0
0
0
0
17
0
0
0
0
0
% R
% Ser:
0
0
0
9
0
0
0
92
0
0
0
9
0
17
92
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
17
9
% T
% Val:
0
0
0
0
0
17
9
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _