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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SPTLC2
All Species:
39.09
Human Site:
Y397
Identified Species:
78.18
UniProt:
O15270
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15270
NP_004854.1
562
62924
Y397
G
K
K
E
L
I
D
Y
L
R
T
H
S
H
S
Chimpanzee
Pan troglodytes
XP_510095
893
98301
Y728
G
K
K
E
L
I
D
Y
L
R
T
H
S
H
S
Rhesus Macaque
Macaca mulatta
XP_001096042
780
85448
Y501
G
K
K
E
L
I
D
Y
L
R
T
H
S
H
S
Dog
Lupus familis
XP_537524
691
75896
Y526
G
K
K
E
L
I
D
Y
L
R
T
H
S
H
S
Cat
Felis silvestris
Mouse
Mus musculus
P97363
560
62963
Y395
G
K
K
E
L
I
D
Y
L
R
T
H
S
H
S
Rat
Rattus norvegicus
NP_001032174
560
62943
Y395
G
K
K
E
L
I
D
Y
L
R
T
H
S
H
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514082
550
62189
Y387
G
S
Q
E
L
V
D
Y
L
R
T
H
S
H
S
Chicken
Gallus gallus
NP_001006483
560
62717
Y395
G
K
K
E
L
I
D
Y
L
R
T
H
S
H
S
Frog
Xenopus laevis
NP_001085763
555
62268
Y390
G
S
K
V
L
I
D
Y
L
R
A
H
S
H
S
Zebra Danio
Brachydanio rerio
NP_001018455
534
60425
A380
H
S
H
S
A
V
Y
A
S
S
M
S
A
P
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784261
549
60922
Y392
G
S
K
E
L
V
D
Y
I
R
V
N
S
H
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P40970
561
63092
R384
A
D
Q
W
I
I
D
R
L
R
L
D
L
T
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
61.9
68.4
78.8
N.A.
96
95.3
N.A.
70.6
87.5
79.1
76.1
N.A.
N.A.
N.A.
N.A.
58.3
Protein Similarity:
100
62.7
70.5
80.7
N.A.
98.5
98.2
N.A.
82.9
92.5
87.7
86.6
N.A.
N.A.
N.A.
N.A.
73.1
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
80
100
80
0
N.A.
N.A.
N.A.
N.A.
66.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
93.3
100
80
13.3
N.A.
N.A.
N.A.
N.A.
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
44.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
63.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
0
9
0
0
9
0
0
9
0
9
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
9
0
0
0
0
92
0
0
0
0
9
0
0
0
% D
% Glu:
0
0
0
75
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
84
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
9
0
9
0
0
0
0
0
0
0
0
75
0
84
0
% H
% Ile:
0
0
0
0
9
75
0
0
9
0
0
0
0
0
0
% I
% Lys:
0
59
75
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
84
0
0
0
84
0
9
0
9
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% P
% Gln:
0
0
17
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
9
0
92
0
0
0
0
0
% R
% Ser:
0
34
0
9
0
0
0
0
9
9
0
9
84
0
84
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
67
0
0
9
9
% T
% Val:
0
0
0
9
0
25
0
0
0
0
9
0
0
0
9
% V
% Trp:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
9
84
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _