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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SPTLC2
All Species:
42.12
Human Site:
Y448
Identified Species:
84.24
UniProt:
O15270
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15270
NP_004854.1
562
62924
Y448
Q
L
A
E
N
T
R
Y
F
R
R
R
L
K
E
Chimpanzee
Pan troglodytes
XP_510095
893
98301
Y779
Q
L
A
E
N
T
R
Y
F
R
R
R
L
K
E
Rhesus Macaque
Macaca mulatta
XP_001096042
780
85448
Y552
Q
L
A
E
N
T
R
Y
F
R
R
R
L
K
E
Dog
Lupus familis
XP_537524
691
75896
Y577
Q
L
A
E
N
T
R
Y
F
R
R
R
L
K
E
Cat
Felis silvestris
Mouse
Mus musculus
P97363
560
62963
Y446
Q
L
A
E
N
T
R
Y
F
R
R
R
L
K
E
Rat
Rattus norvegicus
NP_001032174
560
62943
Y446
Q
L
A
E
N
T
R
Y
F
R
R
R
L
K
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514082
550
62189
Y438
Q
L
A
Q
N
T
R
Y
F
R
K
R
L
H
E
Chicken
Gallus gallus
NP_001006483
560
62717
Y446
Q
L
A
E
N
T
R
Y
F
R
R
R
L
K
E
Frog
Xenopus laevis
NP_001085763
555
62268
Y441
Q
L
A
E
N
T
K
Y
F
R
H
R
L
T
E
Zebra Danio
Brachydanio rerio
NP_001018455
534
60425
I431
R
L
R
E
M
G
F
I
I
Y
G
N
N
D
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784261
549
60922
Y443
A
L
K
R
N
T
Q
Y
F
R
R
R
L
R
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P40970
561
63092
Y435
R
I
A
F
N
S
R
Y
L
R
L
A
L
Q
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
61.9
68.4
78.8
N.A.
96
95.3
N.A.
70.6
87.5
79.1
76.1
N.A.
N.A.
N.A.
N.A.
58.3
Protein Similarity:
100
62.7
70.5
80.7
N.A.
98.5
98.2
N.A.
82.9
92.5
87.7
86.6
N.A.
N.A.
N.A.
N.A.
73.1
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
80
100
80
13.3
N.A.
N.A.
N.A.
N.A.
66.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
93.3
100
86.6
20
N.A.
N.A.
N.A.
N.A.
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
44.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
63.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
84
0
0
0
0
0
0
0
0
9
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% D
% Glu:
0
0
0
75
0
0
0
0
0
0
0
0
0
0
84
% E
% Phe:
0
0
0
9
0
0
9
0
84
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
9
0
0
0
0
9
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
9
0
0
9
0
% H
% Ile:
0
9
0
0
0
0
0
9
9
0
0
0
0
0
0
% I
% Lys:
0
0
9
0
0
0
9
0
0
0
9
0
0
59
0
% K
% Leu:
0
92
0
0
0
0
0
0
9
0
9
0
92
0
0
% L
% Met:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
92
0
0
0
0
0
0
9
9
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
75
0
0
9
0
0
9
0
0
0
0
0
0
9
0
% Q
% Arg:
17
0
9
9
0
0
75
0
0
92
67
84
0
9
9
% R
% Ser:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
9
% S
% Thr:
0
0
0
0
0
84
0
0
0
0
0
0
0
9
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
92
0
9
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _