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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PPM1D
All Species:
19.7
Human Site:
S442
Identified Species:
36.11
UniProt:
O15297
Number Species:
12
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15297
NP_003611.1
605
66675
S442
H
I
P
A
L
V
R
S
N
A
F
S
E
N
F
Chimpanzee
Pan troglodytes
XP_511612
605
66629
S442
H
I
P
A
L
V
R
S
N
A
F
S
E
N
F
Rhesus Macaque
Macaca mulatta
XP_001110891
605
66558
S442
H
I
P
A
L
V
R
S
N
A
F
S
E
N
F
Dog
Lupus familis
XP_852759
729
79555
S566
H
V
P
A
L
V
R
S
N
A
F
S
E
N
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q9QZ67
598
65704
S435
H
I
P
A
L
V
R
S
N
A
F
S
E
K
F
Rat
Rattus norvegicus
P20650
382
42398
S227
E
V
H
D
I
E
R
S
E
E
D
D
Q
F
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510733
468
51371
A313
S
E
P
P
A
E
V
A
P
G
G
H
G
R
S
Chicken
Gallus gallus
XP_415890
478
52722
Y323
S
N
V
I
S
E
K
Y
A
E
L
P
N
E
I
Frog
Xenopus laevis
NP_001085562
554
61512
L397
K
L
S
F
S
E
P
L
P
T
L
V
R
R
N
Zebra Danio
Brachydanio rerio
NP_001007341
534
58704
P379
I
V
I
A
L
P
E
P
G
K
P
H
L
P
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_525074
1427
153887
E800
A
A
A
A
A
A
A
E
A
A
A
V
E
A
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P49596
356
39046
E201
N
C
D
T
K
P
A
E
E
Q
I
V
T
A
F
Sea Urchin
Strong. purpuratus
XP_787213
568
64302
D397
Q
Y
K
R
R
Y
T
D
G
L
E
L
P
K
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
98.5
78.3
N.A.
88.2
21.4
N.A.
59.6
60.9
59.1
49.4
N.A.
20.7
N.A.
20.6
31.5
Protein Similarity:
100
99.6
98.8
79.9
N.A.
92.7
33.5
N.A.
65.4
66.7
72.5
62.4
N.A.
29.5
N.A.
33.2
49.5
P-Site Identity:
100
100
100
86.6
N.A.
93.3
13.3
N.A.
6.6
0
0
13.3
N.A.
20
N.A.
6.6
0
P-Site Similarity:
100
100
100
100
N.A.
93.3
33.3
N.A.
13.3
6.6
6.6
20
N.A.
20
N.A.
13.3
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
8
54
16
8
16
8
16
47
8
0
0
16
0
% A
% Cys:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
8
0
0
0
8
0
0
8
8
0
0
0
% D
% Glu:
8
8
0
0
0
31
8
16
16
16
8
0
47
8
0
% E
% Phe:
0
0
0
8
0
0
0
0
0
0
39
0
0
8
39
% F
% Gly:
0
0
0
0
0
0
0
0
16
8
8
0
8
0
0
% G
% His:
39
0
8
0
0
0
0
0
0
0
0
16
0
0
0
% H
% Ile:
8
31
8
8
8
0
0
0
0
0
8
0
0
0
16
% I
% Lys:
8
0
8
0
8
0
8
0
0
8
0
0
0
16
0
% K
% Leu:
0
8
0
0
47
0
0
8
0
8
16
8
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
8
8
0
0
0
0
0
0
39
0
0
0
8
31
8
% N
% Pro:
0
0
47
8
0
16
8
8
16
0
8
8
8
8
8
% P
% Gln:
8
0
0
0
0
0
0
0
0
8
0
0
8
0
8
% Q
% Arg:
0
0
0
8
8
0
47
0
0
0
0
0
8
16
0
% R
% Ser:
16
0
8
0
16
0
0
47
0
0
0
39
0
0
8
% S
% Thr:
0
0
0
8
0
0
8
0
0
8
0
0
8
0
0
% T
% Val:
0
24
8
0
0
39
8
0
0
0
0
24
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
8
0
8
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _