KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PMM2
All Species:
52.42
Human Site:
S47
Identified Species:
76.89
UniProt:
O15305
Number Species:
15
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15305
NP_000294.1
246
28082
S47
K
I
G
V
V
G
G
S
D
F
E
K
V
Q
E
Chimpanzee
Pan troglodytes
XP_510805
262
29611
S47
K
I
G
V
V
G
G
S
D
F
E
K
V
Q
E
Rhesus Macaque
Macaca mulatta
XP_001102327
246
28005
S47
K
I
G
V
V
G
G
S
D
F
E
K
V
Q
E
Dog
Lupus familis
XP_547133
246
27865
S47
K
I
G
V
V
G
G
S
D
F
E
K
V
Q
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z2M7
242
27638
S43
K
I
G
V
V
G
G
S
D
F
E
K
L
Q
E
Rat
Rattus norvegicus
NP_001100443
242
27690
S43
K
I
G
V
V
G
G
S
D
F
E
K
L
Q
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506595
230
26152
D32
I
G
V
V
G
G
S
D
F
A
K
V
Q
E
Q
Chicken
Gallus gallus
NP_001026639
247
28306
S48
K
V
G
V
V
G
G
S
D
F
E
K
I
K
E
Frog
Xenopus laevis
NP_001087784
246
28053
S46
K
V
G
V
V
G
G
S
D
F
E
K
I
K
E
Zebra Danio
Brachydanio rerio
NP_956378
250
28394
S50
K
V
G
V
V
G
G
S
D
L
D
K
I
K
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VTZ6
254
29648
S52
T
I
G
I
V
G
G
S
D
L
E
K
M
F
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9XUE6
245
28123
I42
D
L
C
M
S
L
L
I
F
F
F
E
L
Q
I
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002320113
246
27837
S48
T
I
G
V
V
G
G
S
D
L
S
K
I
S
E
Maize
Zea mays
NP_001140792
249
28111
S50
T
V
G
V
V
G
G
S
D
L
V
K
I
T
E
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O80840
246
27743
S48
T
I
G
V
V
G
G
S
D
L
S
K
I
S
E
Baker's Yeast
Sacchar. cerevisiae
P07283
254
29044
S54
C
I
G
F
V
G
G
S
D
L
S
K
Q
L
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
83.5
98.3
93.9
N.A.
89.8
91.8
N.A.
80
84.6
76
70.4
N.A.
52.7
N.A.
44.7
N.A.
Protein Similarity:
100
86.2
99.5
97.1
N.A.
94.3
95.1
N.A.
86.9
92.3
90.2
85.5
N.A.
71.2
N.A.
61.3
N.A.
P-Site Identity:
100
100
100
100
N.A.
93.3
93.3
N.A.
13.3
80
80
66.6
N.A.
66.6
N.A.
13.3
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
33.3
100
100
93.3
N.A.
80
N.A.
40
N.A.
Percent
Protein Identity:
58.5
59.8
N.A.
61.7
57.4
N.A.
Protein Similarity:
76
77.5
N.A.
77.6
70.4
N.A.
P-Site Identity:
66.6
60
N.A.
66.6
60
N.A.
P-Site Similarity:
73.3
73.3
N.A.
73.3
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% A
% Cys:
7
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
0
0
0
0
0
7
88
0
7
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
57
7
0
7
88
% E
% Phe:
0
0
0
7
0
0
0
0
13
57
7
0
0
7
0
% F
% Gly:
0
7
88
0
7
94
88
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
7
63
0
7
0
0
0
7
0
0
0
0
38
0
7
% I
% Lys:
57
0
0
0
0
0
0
0
0
0
7
88
0
19
0
% K
% Leu:
0
7
0
0
0
7
7
0
0
38
0
0
19
7
0
% L
% Met:
0
0
0
7
0
0
0
0
0
0
0
0
7
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
13
44
7
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
7
0
7
88
0
0
19
0
0
13
0
% S
% Thr:
25
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% T
% Val:
0
25
7
82
88
0
0
0
0
0
7
7
25
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _