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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PMM2
All Species:
31.52
Human Site:
Y145
Identified Species:
46.22
UniProt:
O15305
Number Species:
15
Phosphosite Substitution
Charge Score:
0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15305
NP_000294.1
246
28082
Y145
Q
E
E
R
I
E
F
Y
E
L
D
K
K
E
N
Chimpanzee
Pan troglodytes
XP_510805
262
29611
Y145
Q
E
E
R
I
E
F
Y
E
L
D
K
K
E
N
Rhesus Macaque
Macaca mulatta
XP_001102327
246
28005
Y145
Q
E
E
R
I
E
F
Y
E
L
D
K
K
E
N
Dog
Lupus familis
XP_547133
246
27865
H145
Q
E
E
R
I
E
F
H
E
L
D
K
K
E
N
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z2M7
242
27638
Y141
Q
E
E
R
I
E
F
Y
E
L
D
K
K
E
H
Rat
Rattus norvegicus
NP_001100443
242
27690
Y141
Q
E
E
R
I
E
F
Y
E
L
D
K
K
E
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506595
230
26152
Y129
Q
E
E
R
L
E
F
Y
E
L
D
Q
K
E
N
Chicken
Gallus gallus
NP_001026639
247
28306
Y146
Q
E
E
R
I
E
F
Y
E
L
D
K
K
E
H
Frog
Xenopus laevis
NP_001087784
246
28053
Y144
Q
E
E
R
I
E
F
Y
E
L
D
K
K
E
Q
Zebra Danio
Brachydanio rerio
NP_956378
250
28394
F148
Q
Q
E
R
I
E
F
F
E
L
D
K
K
E
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VTZ6
254
29648
A151
R
E
E
R
N
M
F
A
E
Y
D
I
E
H
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9XUE6
245
28123
V142
Q
E
E
R
M
Q
F
V
E
F
D
K
K
H
G
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002320113
246
27837
E146
Q
E
E
R
D
E
F
E
K
Y
D
K
V
Q
N
Maize
Zea mays
NP_001140792
249
28111
E148
Q
E
E
R
D
E
F
E
K
Y
D
K
V
H
N
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O80840
246
27743
E146
Q
E
E
R
D
E
F
E
R
Y
D
K
V
Q
N
Baker's Yeast
Sacchar. cerevisiae
P07283
254
29044
E152
T
E
E
R
N
E
F
E
R
Y
D
K
E
H
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
83.5
98.3
93.9
N.A.
89.8
91.8
N.A.
80
84.6
76
70.4
N.A.
52.7
N.A.
44.7
N.A.
Protein Similarity:
100
86.2
99.5
97.1
N.A.
94.3
95.1
N.A.
86.9
92.3
90.2
85.5
N.A.
71.2
N.A.
61.3
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
86.6
93.3
93.3
80
N.A.
40
N.A.
60
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
93.3
93.3
N.A.
53.3
N.A.
73.3
N.A.
Percent
Protein Identity:
58.5
59.8
N.A.
61.7
57.4
N.A.
Protein Similarity:
76
77.5
N.A.
77.6
70.4
N.A.
P-Site Identity:
60
60
N.A.
60
46.6
N.A.
P-Site Similarity:
73.3
66.6
N.A.
66.6
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
19
0
0
0
0
0
100
0
0
0
0
% D
% Glu:
0
94
100
0
0
88
0
25
75
0
0
0
13
63
0
% E
% Phe:
0
0
0
0
0
0
100
7
0
7
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% G
% His:
0
0
0
0
0
0
0
7
0
0
0
0
0
25
19
% H
% Ile:
0
0
0
0
57
0
0
0
0
0
0
7
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
13
0
0
88
69
0
13
% K
% Leu:
0
0
0
0
7
0
0
0
0
63
0
0
0
0
0
% L
% Met:
0
0
0
0
7
7
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
13
0
0
0
0
0
0
0
0
0
50
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
88
7
0
0
0
7
0
0
0
0
0
7
0
13
13
% Q
% Arg:
7
0
0
100
0
0
0
0
13
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
7
0
0
0
0
19
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
50
0
32
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _