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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF3H All Species: 32.73
Human Site: Y125 Identified Species: 51.43
UniProt: O15372 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15372 NP_003747.1 352 39930 Y125 G W Y Q S T Y Y G S F V T R A
Chimpanzee Pan troglodytes XP_001139607 359 40758 Y125 G W Y Q S T Y Y G S F V T R A
Rhesus Macaque Macaca mulatta XP_001093853 352 39928 Y125 G W Y Q S T Y Y G S F V T R A
Dog Lupus familis XP_532315 352 39868 Y125 G W Y Q S T Y Y G S F V T R A
Cat Felis silvestris
Mouse Mus musculus Q91WK2 352 39814 Y125 G W Y Q S T Y Y G S F V T R A
Rat Rattus norvegicus Q6P9U8 352 39887 Y125 G W Y Q S T Y Y G S F V T R A
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q5ZLE6 348 39518 Y121 G W Y Q S T Y Y G S F V T R A
Frog Xenopus laevis Q5PPY6 334 38372 S112 T F Y G T F V S R A L L D S Q
Zebra Danio Brachydanio rerio Q6AXJ2 335 38578 S113 T Y Y G S F V S R A L L D S Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9U9Q4 338 38389 E116 S L S M A L L E S Q Y H Y Q T
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans O01974 365 40946 F118 G F Y Q S H Q F G A G F S H D
Sea Urchin Strong. purpuratus XP_780589 327 37161 T105 T K Y G T F L T K A L L D S Q
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001140776 343 38915 T121 C L L G S F Q T V E L I E T F
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9C5Z2 337 38354 T115 T V L G S Y Q T V E L I E T F
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q7S9Y9 359 40352 V135 Q K E N E K T V A L V H D V S
Conservation
Percent
Protein Identity: 100 98 99.4 98.3 N.A. 97.1 97.7 N.A. N.A. 89.4 79.5 80.6 N.A. 43.7 N.A. 30.6 54.2
Protein Similarity: 100 98 99.4 98.5 N.A. 98.3 98.8 N.A. N.A. 94.3 88 88 N.A. 65 N.A. 51.2 72.1
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. N.A. 100 6.6 13.3 N.A. 0 N.A. 33.3 6.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. N.A. 100 33.3 33.3 N.A. 20 N.A. 60 26.6
Percent
Protein Identity: N.A. 40 N.A. 39.7 N.A. 27.3
Protein Similarity: N.A. 61.3 N.A. 59.6 N.A. 50.4
P-Site Identity: N.A. 6.6 N.A. 6.6 N.A. 0
P-Site Similarity: N.A. 13.3 N.A. 13.3 N.A. 6.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 7 0 0 0 7 27 0 0 0 0 47 % A
% Cys: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 27 0 7 % D
% Glu: 0 0 7 0 7 0 0 7 0 14 0 0 14 0 0 % E
% Phe: 0 14 0 0 0 27 0 7 0 0 47 7 0 0 14 % F
% Gly: 54 0 0 34 0 0 0 0 54 0 7 0 0 0 0 % G
% His: 0 0 0 0 0 7 0 0 0 0 0 14 0 7 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 14 0 0 0 % I
% Lys: 0 14 0 0 0 7 0 0 7 0 0 0 0 0 0 % K
% Leu: 0 14 14 0 0 7 14 0 0 7 34 20 0 0 0 % L
% Met: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 7 0 0 54 0 0 20 0 0 7 0 0 0 7 20 % Q
% Arg: 0 0 0 0 0 0 0 0 14 0 0 0 0 47 0 % R
% Ser: 7 0 7 0 74 0 0 14 7 47 0 0 7 20 7 % S
% Thr: 27 0 0 0 14 47 7 20 0 0 0 0 47 14 7 % T
% Val: 0 7 0 0 0 0 14 7 14 0 7 47 0 7 0 % V
% Trp: 0 47 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 7 74 0 0 7 47 47 0 0 7 0 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _