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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HDAC3 All Species: 30.91
Human Site: S374 Identified Species: 45.33
UniProt: O15379 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15379 NP_003874.2 428 48848 S374 K M L N H A P S V Q I H D V P
Chimpanzee Pan troglodytes XP_001151110 445 50691 S374 K M L N H A P S V Q I H D V P
Rhesus Macaque Macaca mulatta XP_001093955 450 51361 S374 K M L N H A P S V Q I H D V P
Dog Lupus familis XP_858113 353 40330 V300 M L N H A P S V Q I H D V P A
Cat Felis silvestris
Mouse Mus musculus O88895 424 48346 N370 F E N L K M L N H A P S V Q I
Rat Rattus norvegicus Q6P6W3 428 48802 S374 K M L N H A P S V Q I H D V P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P56520 428 48883 S374 K M L N H A P S V Q I H D V P
Frog Xenopus laevis Q6IRL9 428 48935 S374 K M L N H A P S V Q I H D V P
Zebra Danio Brachydanio rerio Q803C3 428 48962 S374 K M L N H A P S V Q I R D V P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q94517 521 58312 V377 M L P H A P G V Q I Q A I P E
Honey Bee Apis mellifera XP_395811 433 49418 S376 K M I Q H S P S V Q M Q D V P
Nematode Worm Caenorhab. elegans O17695 461 52119 V383 Q L T F V P S V Q M R P I P E
Sea Urchin Strong. purpuratus P56518 576 64060 V378 M I P H A P G V Q M Q P I P E
Poplar Tree Populus trichocarpa
Maize Zea mays P56521 513 57528 E392 A P S V H F Q E R V P D T E I
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8H0W2 426 48669 N366 I K V Q I L E N L R Y I Q H A
Baker's Yeast Sacchar. cerevisiae P32561 433 48886 N379 V M T N I F A N L E N T K Y A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 95.5 94.4 82.4 N.A. 98.8 99.7 N.A. N.A. 97.4 94.8 92 N.A. 48.5 70.4 52.4 45.8
Protein Similarity: 100 95.9 94.8 82.4 N.A. 99 100 N.A. N.A. 98.3 97.4 96 N.A. 66.2 84.7 70.7 60.2
P-Site Identity: 100 100 100 0 N.A. 0 100 N.A. N.A. 100 100 93.3 N.A. 0 66.6 0 0
P-Site Similarity: 100 100 100 13.3 N.A. 6.6 100 N.A. N.A. 100 100 93.3 N.A. 13.3 86.6 13.3 13.3
Percent
Protein Identity: N.A. 46.7 N.A. 57.2 54.9 N.A.
Protein Similarity: N.A. 64.3 N.A. 75.4 74.1 N.A.
P-Site Identity: N.A. 6.6 N.A. 0 13.3 N.A.
P-Site Similarity: N.A. 6.6 N.A. 26.6 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 0 0 19 44 7 0 0 7 0 7 0 0 19 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 13 50 0 0 % D
% Glu: 0 7 0 0 0 0 7 7 0 7 0 0 0 7 19 % E
% Phe: 7 0 0 7 0 13 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 13 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 19 57 0 0 0 7 0 7 38 0 7 0 % H
% Ile: 7 7 7 0 13 0 0 0 0 13 44 7 19 0 13 % I
% Lys: 50 7 0 0 7 0 0 0 0 0 0 0 7 0 0 % K
% Leu: 0 19 44 7 0 7 7 0 13 0 0 0 0 0 0 % L
% Met: 19 57 0 0 0 7 0 0 0 13 7 0 0 0 0 % M
% Asn: 0 0 13 50 0 0 0 19 0 0 7 0 0 0 0 % N
% Pro: 0 7 13 0 0 25 50 0 0 0 13 13 0 25 50 % P
% Gln: 7 0 0 13 0 0 7 0 25 50 13 7 7 7 0 % Q
% Arg: 0 0 0 0 0 0 0 0 7 7 7 7 0 0 0 % R
% Ser: 0 0 7 0 0 7 13 50 0 0 0 7 0 0 0 % S
% Thr: 0 0 13 0 0 0 0 0 0 0 0 7 7 0 0 % T
% Val: 7 0 7 7 7 0 0 25 50 7 0 0 13 50 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 7 0 0 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _