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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC3
All Species:
30.61
Human Site:
Y354
Identified Species:
44.89
UniProt:
O15379
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15379
NP_003874.2
428
48848
Y354
E
N
Q
N
S
R
Q
Y
L
D
Q
I
R
Q
T
Chimpanzee
Pan troglodytes
XP_001151110
445
50691
Y354
E
N
Q
N
S
R
Q
Y
L
D
Q
I
R
Q
T
Rhesus Macaque
Macaca mulatta
XP_001093955
450
51361
Y354
E
N
Q
N
S
R
Q
Y
L
D
Q
I
R
Q
T
Dog
Lupus familis
XP_858113
353
40330
L280
N
Q
N
S
R
Q
Y
L
D
Q
I
R
Q
T
I
Cat
Felis silvestris
Mouse
Mus musculus
O88895
424
48346
N350
S
T
R
I
E
N
Q
N
S
R
Q
Y
L
D
Q
Rat
Rattus norvegicus
Q6P6W3
428
48802
Y354
E
N
Q
N
S
R
Q
Y
L
D
Q
I
R
Q
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P56520
428
48883
Y354
E
N
Q
N
S
R
Q
Y
L
D
Q
I
R
Q
T
Frog
Xenopus laevis
Q6IRL9
428
48935
Y354
E
N
Q
N
S
R
Q
Y
L
D
Q
I
R
Q
T
Zebra Danio
Brachydanio rerio
Q803C3
428
48962
Y354
E
N
Q
N
S
R
Q
Y
L
E
Q
I
R
Q
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q94517
521
58312
L357
N
Q
N
T
S
E
Y
L
E
K
I
K
N
R
L
Honey Bee
Apis mellifera
XP_395811
433
49418
Y356
D
N
A
N
S
K
Q
Y
L
E
A
I
T
R
H
Nematode Worm
Caenorhab. elegans
O17695
461
52119
L363
N
E
N
S
S
D
M
L
A
K
L
Q
T
D
V
Sea Urchin
Strong. purpuratus
P56518
576
64060
L358
N
Q
N
T
G
E
Y
L
D
K
I
K
T
R
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P56521
513
57528
L372
N
K
N
T
R
Q
Q
L
D
D
I
R
S
K
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8H0W2
426
48669
H346
S
L
K
I
P
G
G
H
I
E
N
L
N
T
K
Baker's Yeast
Sacchar. cerevisiae
P32561
433
48886
N359
K
L
S
V
R
P
S
N
M
F
N
V
N
T
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.5
94.4
82.4
N.A.
98.8
99.7
N.A.
N.A.
97.4
94.8
92
N.A.
48.5
70.4
52.4
45.8
Protein Similarity:
100
95.9
94.8
82.4
N.A.
99
100
N.A.
N.A.
98.3
97.4
96
N.A.
66.2
84.7
70.7
60.2
P-Site Identity:
100
100
100
0
N.A.
13.3
100
N.A.
N.A.
100
100
93.3
N.A.
6.6
46.6
6.6
0
P-Site Similarity:
100
100
100
20
N.A.
20
100
N.A.
N.A.
100
100
100
N.A.
13.3
73.3
13.3
6.6
Percent
Protein Identity:
N.A.
46.7
N.A.
57.2
54.9
N.A.
Protein Similarity:
N.A.
64.3
N.A.
75.4
74.1
N.A.
P-Site Identity:
N.A.
13.3
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
33.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
0
0
0
0
0
7
0
7
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
0
0
0
7
0
0
19
44
0
0
0
13
0
% D
% Glu:
44
7
0
0
7
13
0
0
7
19
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% F
% Gly:
0
0
0
0
7
7
7
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
7
% H
% Ile:
0
0
0
13
0
0
0
0
7
0
25
50
0
0
7
% I
% Lys:
7
7
7
0
0
7
0
0
0
19
0
13
0
7
7
% K
% Leu:
0
13
0
0
0
0
0
32
50
0
7
7
7
0
19
% L
% Met:
0
0
0
0
0
0
7
0
7
0
0
0
0
0
0
% M
% Asn:
32
50
32
50
0
7
0
13
0
0
13
0
19
0
0
% N
% Pro:
0
0
0
0
7
7
0
0
0
0
0
0
0
0
7
% P
% Gln:
0
19
44
0
0
13
63
0
0
7
50
7
7
44
7
% Q
% Arg:
0
0
7
0
19
44
0
0
0
7
0
13
44
19
0
% R
% Ser:
13
0
7
13
63
0
7
0
7
0
0
0
7
0
0
% S
% Thr:
0
7
0
19
0
0
0
0
0
0
0
0
19
19
44
% T
% Val:
0
0
0
7
0
0
0
0
0
0
0
7
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
19
50
0
0
0
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _