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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NVL All Species: 17.58
Human Site: S159 Identified Species: 25.78
UniProt: O15381 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15381 NP_002524.2 856 95051 S159 R I S S K T G S I P L K T P A
Chimpanzee Pan troglodytes XP_514229 905 100536 S193 Q I S S K T G S I P L K T P A
Rhesus Macaque Macaca mulatta XP_001096627 856 94931 S159 Q I S S K T G S V P L K T P A
Dog Lupus familis XP_537239 955 104441 S232 R M P S G T G S G P L K A P A
Cat Felis silvestris
Mouse Mus musculus Q9DBY8 855 94457 S158 L L T S K T G S V P L K T P A
Rat Rattus norvegicus P46462 806 89330 L140 V Y L K P Y F L E A Y R P I R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512479 677 74669 G87 L K F E D V G G N D A T L K E
Chicken Gallus gallus
Frog Xenopus laevis P23787 805 89193 L140 V Y L K P Y F L E A Y R P I R
Zebra Danio Brachydanio rerio Q7ZU99 806 89405 L140 V Y L K P Y F L E A Y R P I R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7KN62 801 88841 Y140 K P Y F L E A Y R P I H M G D
Honey Bee Apis mellifera XP_392923 818 90486 Q140 T H A K E I E Q L R R P S K E
Nematode Worm Caenorhab. elegans P54812 810 89622 P142 L F D V F L R P Y F T D A Y R
Sea Urchin Strong. purpuratus XP_785648 742 81148 D142 E M S N V T L D L A G V G D P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SS94 820 89986 V145 V S T S E D A V Y G E K L S P
Baker's Yeast Sacchar. cerevisiae Q07844 837 93051 K155 R I T S T W S K S G S V S E S
Red Bread Mold Neurospora crassa Q7SGP2 1381 148356 Q260 K R S S A S G Q Q Q G R K L N
Conservation
Percent
Protein Identity: 100 92.3 97.6 77.2 N.A. 87.8 35.9 N.A. 65.7 N.A. 35.9 35.7 N.A. 33.8 49.2 35.8 48.1
Protein Similarity: 100 93.1 98.5 83.1 N.A. 93.2 54.2 N.A. 72.1 N.A. 53.3 54.2 N.A. 54.2 65.1 54.2 60.5
P-Site Identity: 100 93.3 86.6 66.6 N.A. 73.3 0 N.A. 6.6 N.A. 0 0 N.A. 6.6 0 0 13.3
P-Site Similarity: 100 100 100 73.3 N.A. 93.3 6.6 N.A. 6.6 N.A. 6.6 6.6 N.A. 20 26.6 0 33.3
Percent
Protein Identity: N.A. N.A. N.A. 37.8 42.2 22.9
Protein Similarity: N.A. N.A. N.A. 57 61.5 38.1
P-Site Identity: N.A. N.A. N.A. 13.3 20 20
P-Site Similarity: N.A. N.A. N.A. 26.6 40 40
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 7 0 7 0 13 0 0 25 7 0 13 0 32 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 7 0 7 7 0 7 0 7 0 7 0 7 7 % D
% Glu: 7 0 0 7 13 7 7 0 19 0 7 0 0 7 13 % E
% Phe: 0 7 7 7 7 0 19 0 0 7 0 0 0 0 0 % F
% Gly: 0 0 0 0 7 0 44 7 7 13 13 0 7 7 0 % G
% His: 0 7 0 0 0 0 0 0 0 0 0 7 0 0 0 % H
% Ile: 0 25 0 0 0 7 0 0 13 0 7 0 0 19 0 % I
% Lys: 13 7 0 25 25 0 0 7 0 0 0 38 7 13 0 % K
% Leu: 19 7 19 0 7 7 7 19 13 0 32 0 13 7 0 % L
% Met: 0 13 0 0 0 0 0 0 0 0 0 0 7 0 0 % M
% Asn: 0 0 0 7 0 0 0 0 7 0 0 0 0 0 7 % N
% Pro: 0 7 7 0 19 0 0 7 0 38 0 7 19 32 13 % P
% Gln: 13 0 0 0 0 0 0 13 7 7 0 0 0 0 0 % Q
% Arg: 19 7 0 0 0 0 7 0 7 7 7 25 0 0 25 % R
% Ser: 0 7 32 50 0 7 7 32 7 0 7 0 13 7 7 % S
% Thr: 7 0 19 0 7 38 0 0 0 0 7 7 25 0 0 % T
% Val: 25 0 0 7 7 7 0 7 13 0 0 13 0 0 0 % V
% Trp: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 19 7 0 0 19 0 7 13 0 19 0 0 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _