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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NVL All Species: 13.03
Human Site: S195 Identified Species: 19.11
UniProt: O15381 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15381 NP_002524.2 856 95051 S195 L D L S C E K S N P K K P I T
Chimpanzee Pan troglodytes XP_514229 905 100536 S229 L D L S C E K S N P K K P I T
Rhesus Macaque Macaca mulatta XP_001096627 856 94931 S195 L D L S D E K S D P K K S I T
Dog Lupus familis XP_537239 955 104441 P268 E K S N H K Q P G S E K E D S
Cat Felis silvestris
Mouse Mus musculus Q9DBY8 855 94457 S194 L D L S D D Q S N S K K Q D S
Rat Rattus norvegicus P46462 806 89330 V176 D P S P Y C I V A P D T V I H
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512479 677 74669 G123 P R G F L L H G P P G C G K T
Chicken Gallus gallus
Frog Xenopus laevis P23787 805 89193 V176 D P S P Y C I V A P D T V I H
Zebra Danio Brachydanio rerio Q7ZU99 806 89405 V176 D P S P Y C I V A P D T V I H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7KN62 801 88841 E176 P Y C I V A P E T V I F C D G
Honey Bee Apis mellifera XP_392923 818 90486 D176 S A K K R Q R D E D A D C Q F
Nematode Worm Caenorhab. elegans P54812 810 89622 A178 V E T D P A P A C I V A P D T
Sea Urchin Strong. purpuratus XP_785648 742 81148 N178 K E E S A Q E N S S Q N D S F
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SS94 820 89986 A181 K K P I G S P A E K N V E V E
Baker's Yeast Sacchar. cerevisiae Q07844 837 93051 Q191 G T C K V K R Q K I K E D R S
Red Bread Mold Neurospora crassa Q7SGP2 1381 148356 T296 T N A Q T A E T D A D D T E F
Conservation
Percent
Protein Identity: 100 92.3 97.6 77.2 N.A. 87.8 35.9 N.A. 65.7 N.A. 35.9 35.7 N.A. 33.8 49.2 35.8 48.1
Protein Similarity: 100 93.1 98.5 83.1 N.A. 93.2 54.2 N.A. 72.1 N.A. 53.3 54.2 N.A. 54.2 65.1 54.2 60.5
P-Site Identity: 100 100 80 6.6 N.A. 53.3 13.3 N.A. 13.3 N.A. 13.3 13.3 N.A. 0 0 13.3 6.6
P-Site Similarity: 100 100 86.6 40 N.A. 73.3 13.3 N.A. 13.3 N.A. 13.3 13.3 N.A. 0 13.3 33.3 46.6
Percent
Protein Identity: N.A. N.A. N.A. 37.8 42.2 22.9
Protein Similarity: N.A. N.A. N.A. 57 61.5 38.1
P-Site Identity: N.A. N.A. N.A. 0 6.6 0
P-Site Similarity: N.A. N.A. N.A. 13.3 33.3 26.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 7 0 7 19 0 13 19 7 7 7 0 0 0 % A
% Cys: 0 0 13 0 13 19 0 0 7 0 0 7 13 0 0 % C
% Asp: 19 25 0 7 13 7 0 7 13 7 25 13 13 25 0 % D
% Glu: 7 13 7 0 0 19 13 7 13 0 7 7 13 7 7 % E
% Phe: 0 0 0 7 0 0 0 0 0 0 0 7 0 0 19 % F
% Gly: 7 0 7 0 7 0 0 7 7 0 7 0 7 0 7 % G
% His: 0 0 0 0 7 0 7 0 0 0 0 0 0 0 19 % H
% Ile: 0 0 0 13 0 0 19 0 0 13 7 0 0 38 0 % I
% Lys: 13 13 7 13 0 13 19 0 7 7 32 32 0 7 0 % K
% Leu: 25 0 25 0 7 7 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 7 0 7 0 0 0 7 19 0 7 7 0 0 0 % N
% Pro: 13 19 7 19 7 0 19 7 7 44 0 0 19 0 0 % P
% Gln: 0 0 0 7 0 13 13 7 0 0 7 0 7 7 0 % Q
% Arg: 0 7 0 0 7 0 13 0 0 0 0 0 0 7 0 % R
% Ser: 7 0 25 32 0 7 0 25 7 19 0 0 7 7 19 % S
% Thr: 7 7 7 0 7 0 0 7 7 0 0 19 7 0 32 % T
% Val: 7 0 0 0 13 0 0 19 0 7 7 7 19 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 7 0 0 19 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _