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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NVL All Species: 16.67
Human Site: S260 Identified Species: 24.44
UniProt: O15381 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15381 NP_002524.2 856 95051 S260 R G L E F Q I S N V K F E D V
Chimpanzee Pan troglodytes XP_514229 905 100536 S294 R G L E F Q I S N V K F E D V
Rhesus Macaque Macaca mulatta XP_001096627 856 94931 S260 R G L E F Q I S N V K F E D V
Dog Lupus familis XP_537239 955 104441 S327 K G L E L Q V S R V K F E D V
Cat Felis silvestris
Mouse Mus musculus Q9DBY8 855 94457 S259 R S T E L Q I S N V K F E D V
Rat Rattus norvegicus P46462 806 89330 L224 K E M V E L P L R H P A L F K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512479 677 74669 A171 L R E L F E Q A V S S A P C I
Chicken Gallus gallus
Frog Xenopus laevis P23787 805 89193 L224 K E M V E L P L R H P A L F K
Zebra Danio Brachydanio rerio Q7ZU99 806 89405 L224 K E M V E L P L R H P A L F K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7KN62 801 88841 P224 V E L P L R H P S L F K A I G
Honey Bee Apis mellifera XP_392923 818 90486 I225 P K I T F S D I G G N D K V L
Nematode Worm Caenorhab. elegans P54812 810 89622 E226 A Q I K E M V E L P L R H P Q
Sea Urchin Strong. purpuratus XP_785648 742 81148 G226 R S S E S E G G R K G K K K V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SS94 820 89986 G229 L E V E G T K G P T F K D F G
Baker's Yeast Sacchar. cerevisiae Q07844 837 93051 G241 T G V E P P R G V L L H G P P
Red Bread Mold Neurospora crassa Q7SGP2 1381 148356 P396 P D L L H P K P T P E D D E E
Conservation
Percent
Protein Identity: 100 92.3 97.6 77.2 N.A. 87.8 35.9 N.A. 65.7 N.A. 35.9 35.7 N.A. 33.8 49.2 35.8 48.1
Protein Similarity: 100 93.1 98.5 83.1 N.A. 93.2 54.2 N.A. 72.1 N.A. 53.3 54.2 N.A. 54.2 65.1 54.2 60.5
P-Site Identity: 100 100 100 73.3 N.A. 80 0 N.A. 6.6 N.A. 0 0 N.A. 6.6 6.6 0 20
P-Site Similarity: 100 100 100 86.6 N.A. 80 13.3 N.A. 26.6 N.A. 13.3 13.3 N.A. 26.6 26.6 20 33.3
Percent
Protein Identity: N.A. N.A. N.A. 37.8 42.2 22.9
Protein Similarity: N.A. N.A. N.A. 57 61.5 38.1
P-Site Identity: N.A. N.A. N.A. 6.6 13.3 6.6
P-Site Similarity: N.A. N.A. N.A. 20 26.6 26.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 0 0 0 0 0 7 0 0 0 25 7 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % C
% Asp: 0 7 0 0 0 0 7 0 0 0 0 13 13 32 0 % D
% Glu: 0 32 7 50 25 13 0 7 0 0 7 0 32 7 7 % E
% Phe: 0 0 0 0 32 0 0 0 0 0 13 32 0 25 0 % F
% Gly: 0 32 0 0 7 0 7 19 7 7 7 0 7 0 13 % G
% His: 0 0 0 0 7 0 7 0 0 19 0 7 7 0 0 % H
% Ile: 0 0 13 0 0 0 25 7 0 0 0 0 0 7 7 % I
% Lys: 25 7 0 7 0 0 13 0 0 7 32 19 13 7 19 % K
% Leu: 13 0 38 13 19 19 0 19 7 13 13 0 19 0 7 % L
% Met: 0 0 19 0 0 7 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 25 0 7 0 0 0 0 % N
% Pro: 13 0 0 7 7 13 19 13 7 13 19 0 7 13 7 % P
% Gln: 0 7 0 0 0 32 7 0 0 0 0 0 0 0 7 % Q
% Arg: 32 7 0 0 0 7 7 0 32 0 0 7 0 0 0 % R
% Ser: 0 13 7 0 7 7 0 32 7 7 7 0 0 0 0 % S
% Thr: 7 0 7 7 0 7 0 0 7 7 0 0 0 0 0 % T
% Val: 7 0 13 19 0 0 13 0 13 32 0 0 0 7 38 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _