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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NVL All Species: 26.06
Human Site: S508 Identified Species: 38.22
UniProt: O15381 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15381 NP_002524.2 856 95051 S508 P E M E D L P S K G V Q E E R
Chimpanzee Pan troglodytes XP_514229 905 100536 S542 P E M E D L P S K G V Q E E R
Rhesus Macaque Macaca mulatta XP_001096627 856 94931 S508 P E M E D L P S K G V Q E E S
Dog Lupus familis XP_537239 955 104441 S575 P E M G T L P S K G G Q E D R
Cat Felis silvestris
Mouse Mus musculus Q9DBY8 855 94457 S507 P E I E G L P S E G D Q E E R
Rat Rattus norvegicus P46462 806 89330 S416 A D L A A L C S E A A L Q A I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512479 677 74669 S360 L E L L K E Q S P L L E E Q L
Chicken Gallus gallus
Frog Xenopus laevis P23787 805 89193 S416 A D L A A L C S E A A L Q A I
Zebra Danio Brachydanio rerio Q7ZU99 806 89405 S416 A D L A A L C S E A A L Q A I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7KN62 801 88841 S413 A D L A S L C S E A A L Q Q I
Honey Bee Apis mellifera XP_392923 818 90486 N478 K K T E N F E N S G N L V D E
Nematode Worm Caenorhab. elegans P54812 810 89622 L416 H G F V G A D L A S L C S E A
Sea Urchin Strong. purpuratus XP_785648 742 81148 K415 S L G I P D E K A R T R I L H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SS94 820 89986 G458 E S V A Y L A G R K A I K R I
Baker's Yeast Sacchar. cerevisiae Q07844 837 93051 N461 M E I D E T A N G D E S S L K
Red Bread Mold Neurospora crassa Q7SGP2 1381 148356 D862 T E V E K V P D G I R A L F T
Conservation
Percent
Protein Identity: 100 92.3 97.6 77.2 N.A. 87.8 35.9 N.A. 65.7 N.A. 35.9 35.7 N.A. 33.8 49.2 35.8 48.1
Protein Similarity: 100 93.1 98.5 83.1 N.A. 93.2 54.2 N.A. 72.1 N.A. 53.3 54.2 N.A. 54.2 65.1 54.2 60.5
P-Site Identity: 100 100 93.3 73.3 N.A. 73.3 13.3 N.A. 20 N.A. 13.3 13.3 N.A. 13.3 13.3 6.6 0
P-Site Similarity: 100 100 93.3 80 N.A. 86.6 40 N.A. 46.6 N.A. 40 40 N.A. 46.6 40 13.3 6.6
Percent
Protein Identity: N.A. N.A. N.A. 37.8 42.2 22.9
Protein Similarity: N.A. N.A. N.A. 57 61.5 38.1
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 20
P-Site Similarity: N.A. N.A. N.A. 26.6 40 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 25 0 0 32 19 7 13 0 13 25 32 7 0 19 7 % A
% Cys: 0 0 0 0 0 0 25 0 0 0 0 7 0 0 0 % C
% Asp: 0 25 0 7 19 7 7 7 0 7 7 0 0 13 0 % D
% Glu: 7 50 0 38 7 7 13 0 32 0 7 7 38 32 7 % E
% Phe: 0 0 7 0 0 7 0 0 0 0 0 0 0 7 0 % F
% Gly: 0 7 7 7 13 0 0 7 13 38 7 0 0 0 0 % G
% His: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % H
% Ile: 0 0 13 7 0 0 0 0 0 7 0 7 7 0 32 % I
% Lys: 7 7 0 0 13 0 0 7 25 7 0 0 7 0 7 % K
% Leu: 7 7 32 7 0 63 0 7 0 7 13 32 7 13 7 % L
% Met: 7 0 25 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 7 0 0 13 0 0 7 0 0 0 0 % N
% Pro: 32 0 0 0 7 0 38 0 7 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 7 0 0 0 0 32 25 13 0 % Q
% Arg: 0 0 0 0 0 0 0 0 7 7 7 7 0 7 25 % R
% Ser: 7 7 0 0 7 0 0 63 7 7 0 7 13 0 7 % S
% Thr: 7 0 7 0 7 7 0 0 0 0 7 0 0 0 7 % T
% Val: 0 0 13 7 0 7 0 0 0 0 19 0 7 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _