Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NVL All Species: 17.88
Human Site: Y20 Identified Species: 26.22
UniProt: O15381 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.27
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15381 NP_002524.2 856 95051 Y20 L K Q R V I Q Y L T S N K C G
Chimpanzee Pan troglodytes XP_514229 905 100536 Y20 L K Q R V I Q Y L T S N K C G
Rhesus Macaque Macaca mulatta XP_001096627 856 94931 Y20 L K Q R V I Q Y L T G N K C G
Dog Lupus familis XP_537239 955 104441 Y93 V A Q P P S G Y L T S N R C G
Cat Felis silvestris
Mouse Mus musculus Q9DBY8 855 94457 Y20 L K Q R V I Q Y L S S N R C G
Rat Rattus norvegicus P46462 806 89330 K8 M A S G A D S K G D D L S T A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512479 677 74669
Chicken Gallus gallus
Frog Xenopus laevis P23787 805 89193 K8 M A S G S D T K S D D L S T A
Zebra Danio Brachydanio rerio Q7ZU99 806 89405 K8 M A S G G E S K N D D L S T A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7KN62 801 88841 D8 M A D S K G E D L A T A I L K
Honey Bee Apis mellifera XP_392923 818 90486 K8 M A D A L Q K K Y K D Y R I K
Nematode Worm Caenorhab. elegans P54812 810 89622 R8 M A S V P T Q R D E K E K K N
Sea Urchin Strong. purpuratus XP_785648 742 81148 Q9 A P G K H S R Q S G S D R K Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SS94 820 89986 G10 R R G R G G G G G M G G G I N
Baker's Yeast Sacchar. cerevisiae Q07844 837 93051 S10 K V K S K K N S L T S S L D N
Red Bread Mold Neurospora crassa Q7SGP2 1381 148356 F100 V A P S T V Q F S P S S L A L
Conservation
Percent
Protein Identity: 100 92.3 97.6 77.2 N.A. 87.8 35.9 N.A. 65.7 N.A. 35.9 35.7 N.A. 33.8 49.2 35.8 48.1
Protein Similarity: 100 93.1 98.5 83.1 N.A. 93.2 54.2 N.A. 72.1 N.A. 53.3 54.2 N.A. 54.2 65.1 54.2 60.5
P-Site Identity: 100 100 93.3 53.3 N.A. 86.6 0 N.A. 0 N.A. 0 0 N.A. 6.6 0 13.3 6.6
P-Site Similarity: 100 100 93.3 66.6 N.A. 100 6.6 N.A. 0 N.A. 6.6 6.6 N.A. 26.6 26.6 20 33.3
Percent
Protein Identity: N.A. N.A. N.A. 37.8 42.2 22.9
Protein Similarity: N.A. N.A. N.A. 57 61.5 38.1
P-Site Identity: N.A. N.A. N.A. 6.6 20 13.3
P-Site Similarity: N.A. N.A. N.A. 13.3 33.3 40
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 50 0 7 7 0 0 0 0 7 0 7 0 7 19 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 32 0 % C
% Asp: 0 0 13 0 0 13 0 7 7 19 25 7 0 7 0 % D
% Glu: 0 0 0 0 0 7 7 0 0 7 0 7 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 % F
% Gly: 0 0 13 19 13 13 13 7 13 7 13 7 7 0 32 % G
% His: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 25 0 0 0 0 0 0 7 13 0 % I
% Lys: 7 25 7 7 13 7 7 25 0 7 7 0 25 13 13 % K
% Leu: 25 0 0 0 7 0 0 0 44 0 0 19 13 7 7 % L
% Met: 38 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 7 0 7 0 0 32 0 0 19 % N
% Pro: 0 7 7 7 13 0 0 0 0 7 0 0 0 0 0 % P
% Gln: 0 0 32 0 0 7 38 7 0 0 0 0 0 0 7 % Q
% Arg: 7 7 0 32 0 0 7 7 0 0 0 0 25 0 0 % R
% Ser: 0 0 25 19 7 13 13 7 19 7 44 13 19 0 0 % S
% Thr: 0 0 0 0 7 7 7 0 0 32 7 0 0 19 0 % T
% Val: 13 7 0 7 25 7 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 32 7 0 0 7 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _