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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: IPO8 All Species: 42.73
Human Site: Y137 Identified Species: 78.33
UniProt: O15397 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15397 NP_006381.2 1037 119938 Y137 V V D K I D Y Y L Q S Q S S A
Chimpanzee Pan troglodytes XP_528766 1037 119920 Y137 V V D K I D Y Y L Q S Q S S A
Rhesus Macaque Macaca mulatta XP_001082349 1037 119946 Y137 V V D K I D Y Y L Q S Q S S G
Dog Lupus familis XP_852181 1037 119835 Y137 V V D K I D Y Y L Q S Q S S G
Cat Felis silvestris
Mouse Mus musculus Q7TMY7 1010 117031 Y137 V V D K I D Y Y L Q S P N S G
Rat Rattus norvegicus NP_001101015 1038 119470 Y136 I V D K I G F Y L Q S D N S A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507938 1038 119442 Y136 V V D K I G F Y L Q S D N S A
Chicken Gallus gallus XP_416373 1171 133054 Y263 V V D K I G Y Y L Q S Q N S G
Frog Xenopus laevis NP_001079634 1038 119416 Y136 V V E K I G F Y L Q S D N S A
Zebra Danio Brachydanio rerio NP_001037799 1015 117086 Y137 V V D K I N L Y L Q S Q N S G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_524780 1049 119292 Y138 V V D S I S I Y L Q N Q D V N
Honey Bee Apis mellifera XP_624116 1028 117714 Y106 I V D K I T I Y L Q N S D A S
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P46970 1048 119965 L143 L L P N S L E L L A N E D I T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 99.7 96.6 N.A. 89.9 64.3 N.A. 64.8 77.2 63 71 N.A. 48.9 52.1 N.A. N.A.
Protein Similarity: 100 99.9 99.7 98 N.A. 94.5 79.3 N.A. 79.3 82.8 78.1 84 N.A. 69.2 71.3 N.A. N.A.
P-Site Identity: 100 100 93.3 93.3 N.A. 80 66.6 N.A. 73.3 80 66.6 73.3 N.A. 53.3 46.6 N.A. N.A.
P-Site Similarity: 100 100 93.3 93.3 N.A. 86.6 86.6 N.A. 86.6 86.6 86.6 86.6 N.A. 60 73.3 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 25.6 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 46.6 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 8 0 0 0 8 39 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 85 0 0 39 0 0 0 0 0 24 24 0 0 % D
% Glu: 0 0 8 0 0 0 8 0 0 0 0 8 0 0 0 % E
% Phe: 0 0 0 0 0 0 24 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 31 0 0 0 0 0 0 0 0 39 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 16 0 0 0 93 0 16 0 0 0 0 0 0 8 0 % I
% Lys: 0 0 0 85 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 8 8 0 0 0 8 8 8 100 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 8 0 8 0 0 0 0 24 0 47 0 8 % N
% Pro: 0 0 8 0 0 0 0 0 0 0 0 8 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 93 0 54 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 8 8 8 0 0 0 0 77 8 31 77 8 % S
% Thr: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 8 % T
% Val: 77 93 0 0 0 0 0 0 0 0 0 0 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 47 93 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _