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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ABCC4 All Species: 46.36
Human Site: Y556 Identified Species: 85
UniProt: O15439 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15439 NP_001098985.1 1325 149527 Y556 V Y Q D A D I Y L L D D P L S
Chimpanzee Pan troglodytes XP_001137085 1325 149612 Y556 V Y Q D A D I Y L L D D P L S
Rhesus Macaque Macaca mulatta XP_001084757 859 96617 T145 A T V L T V C T L I L A I L H
Dog Lupus familis XP_542642 1516 170242 Y747 V Y Q D A D I Y L L D D P L S
Cat Felis silvestris
Mouse Mus musculus O35379 1528 171166 Y789 V Y S N S D I Y L F D D P L S
Rat Rattus norvegicus Q8CG09 1532 171475 Y790 V Y C N S D I Y L L D D P L S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512380 1314 148498 Y544 V Y Q D A D I Y L L D D P L S
Chicken Gallus gallus Q5F364 1525 170953 Y786 V Y C N A D T Y L F D D P L S
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001007039 1327 149226 Y558 V Y Q D A D I Y L L D D P L S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P91660 1290 143990 Y562 V Y R K A S I Y L L D D P L S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001190458 1362 153036 Y595 V Y H E A D A Y L L D D P L S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q42093 1623 182111 Y761 V Y S N S D V Y I F D D P L S
Baker's Yeast Sacchar. cerevisiae P39109 1515 171103 Y774 V Y A R A D T Y L L D D P L A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 62.9 78 N.A. 33.1 32 N.A. 81.3 33.8 N.A. 69.3 N.A. 40.9 N.A. N.A. 49.6
Protein Similarity: 100 99.8 63.9 82.4 N.A. 53.6 52 N.A. 89.6 52.9 N.A. 82.8 N.A. 62.7 N.A. N.A. 67.4
P-Site Identity: 100 100 13.3 100 N.A. 73.3 80 N.A. 100 73.3 N.A. 100 N.A. 80 N.A. N.A. 80
P-Site Similarity: 100 100 20 100 N.A. 86.6 93.3 N.A. 100 80 N.A. 100 N.A. 86.6 N.A. N.A. 86.6
Percent
Protein Identity: N.A. N.A. N.A. 31.1 33.5 N.A.
Protein Similarity: N.A. N.A. N.A. 48.5 51.6 N.A.
P-Site Identity: N.A. N.A. N.A. 60 73.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 86.6 80 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 8 0 70 0 8 0 0 0 0 8 0 0 8 % A
% Cys: 0 0 16 0 0 0 8 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 39 0 85 0 0 0 0 93 93 0 0 0 % D
% Glu: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 24 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 8 % H
% Ile: 0 0 0 0 0 0 62 0 8 8 0 0 8 0 0 % I
% Lys: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 8 0 0 0 0 93 70 8 0 0 100 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 31 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 93 0 0 % P
% Gln: 0 0 39 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 8 8 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 16 0 24 8 0 0 0 0 0 0 0 0 85 % S
% Thr: 0 8 0 0 8 0 16 8 0 0 0 0 0 0 0 % T
% Val: 93 0 8 0 0 8 8 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 93 0 0 0 0 0 93 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _