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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TLR3
All Species:
13.33
Human Site:
T693
Identified Species:
41.9
UniProt:
O15455
Number Species:
7
Phosphosite Substitution
Charge Score:
-0.29
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15455
NP_003256.1
904
103829
T693
F
P
V
R
L
F
D
T
S
S
C
K
D
S
A
Chimpanzee
Pan troglodytes
NP_001123942
904
103783
T693
F
P
V
R
L
F
D
T
S
S
C
K
D
S
A
Rhesus Macaque
Macaca mulatta
B3Y618
784
90053
R611
L
M
G
V
L
C
H
R
F
H
G
L
W
Y
M
Dog
Lupus familis
XP_540020
905
103952
I694
F
P
V
M
L
F
D
I
S
P
C
K
D
S
A
Cat
Felis silvestris
Mouse
Mus musculus
Q99MB1
905
103653
T694
F
P
L
K
L
F
D
T
S
S
C
K
D
S
A
Rat
Rattus norvegicus
NP_942086
905
103156
T694
L
P
V
K
L
F
D
T
S
S
C
K
D
S
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q9DGB6
781
89077
K608
I
L
V
V
V
G
Y
K
Y
H
A
V
W
Y
M
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001013287
903
102379
P693
H
S
V
M
N
F
D
P
L
S
C
K
D
M
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.8
24.2
83.8
N.A.
79.3
80.2
N.A.
N.A.
22.3
N.A.
48.4
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.8
43.6
90.8
N.A.
87.8
87.8
N.A.
N.A.
43.9
N.A.
65.4
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
6.6
80
N.A.
86.6
86.6
N.A.
N.A.
6.6
N.A.
46.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
6.6
80
N.A.
100
93.3
N.A.
N.A.
13.3
N.A.
46.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
13
0
0
0
63
% A
% Cys:
0
0
0
0
0
13
0
0
0
0
75
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
75
0
0
0
0
0
75
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
50
0
0
0
0
75
0
0
13
0
0
0
0
0
0
% F
% Gly:
0
0
13
0
0
13
0
0
0
0
13
0
0
0
0
% G
% His:
13
0
0
0
0
0
13
0
0
25
0
0
0
0
0
% H
% Ile:
13
0
0
0
0
0
0
13
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
25
0
0
0
13
0
0
0
75
0
0
0
% K
% Leu:
25
13
13
0
75
0
0
0
13
0
0
13
0
0
0
% L
% Met:
0
13
0
25
0
0
0
0
0
0
0
0
0
13
25
% M
% Asn:
0
0
0
0
13
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
63
0
0
0
0
0
13
0
13
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
25
0
0
0
13
0
0
0
0
0
0
0
% R
% Ser:
0
13
0
0
0
0
0
0
63
63
0
0
0
63
0
% S
% Thr:
0
0
0
0
0
0
0
50
0
0
0
0
0
0
13
% T
% Val:
0
0
75
25
13
0
0
0
0
0
0
13
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
25
0
0
% W
% Tyr:
0
0
0
0
0
0
13
0
13
0
0
0
0
25
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _