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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH4
All Species:
31.52
Human Site:
S568
Identified Species:
57.78
UniProt:
O15457
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15457
NP_002431.2
936
104756
S568
S
K
V
K
N
S
Y
S
F
T
S
A
D
L
I
Chimpanzee
Pan troglodytes
XP_524742
936
104699
S568
S
K
V
K
N
S
Y
S
F
T
S
A
D
L
I
Rhesus Macaque
Macaca mulatta
XP_001101368
936
104714
S568
S
K
V
K
N
S
Y
S
F
T
S
A
D
L
I
Dog
Lupus familis
XP_855503
868
98317
T502
V
K
S
S
Y
T
F
T
S
A
D
L
I
K
M
Cat
Felis silvestris
Mouse
Mus musculus
Q99MT2
958
106988
S590
S
K
V
K
N
S
Y
S
F
T
S
A
D
L
I
Rat
Rattus norvegicus
NP_001099947
911
101941
T545
V
K
N
S
Y
S
F
T
S
A
D
L
I
K
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518846
513
58655
S147
T
K
M
K
N
A
Y
S
F
T
S
A
D
L
I
Chicken
Gallus gallus
XP_422549
814
91812
Y448
V
T
K
T
R
N
T
Y
S
F
T
S
A
D
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_688406
931
103864
S560
S
K
Q
K
N
N
F
S
F
T
T
L
D
L
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23405
842
96312
T476
F
R
N
R
T
T
V
T
F
N
S
R
K
V
I
Sea Urchin
Strong. purpuratus
XP_780878
741
83454
Y375
G
L
M
L
R
T
S
Y
S
T
A
R
G
F
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_193469
792
88996
T426
G
K
L
P
N
K
F
T
Q
V
V
K
H
G
K
Baker's Yeast
Sacchar. cerevisiae
P40965
878
99203
I512
A
T
L
P
D
V
F
I
S
R
T
I
K
K
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
97.5
86.6
N.A.
83.4
86
N.A.
47.9
70.5
N.A.
57.7
N.A.
N.A.
N.A.
26.8
50.4
Protein Similarity:
100
99.7
98.4
89.3
N.A.
88.8
91.1
N.A.
51.7
78.4
N.A.
75.8
N.A.
N.A.
N.A.
47
65
P-Site Identity:
100
100
100
6.6
N.A.
100
13.3
N.A.
80
0
N.A.
60
N.A.
N.A.
N.A.
20
6.6
P-Site Similarity:
100
100
100
33.3
N.A.
100
33.3
N.A.
100
26.6
N.A.
86.6
N.A.
N.A.
N.A.
53.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
31.9
29.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
51.3
50.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
8
0
0
0
16
8
39
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
8
0
0
0
0
0
16
0
47
8
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
8
0
0
0
0
0
39
0
54
8
0
0
0
8
8
% F
% Gly:
16
0
0
0
0
0
0
0
0
0
0
0
8
8
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% H
% Ile:
0
0
0
0
0
0
0
8
0
0
0
8
16
0
47
% I
% Lys:
0
70
8
47
0
8
0
0
0
0
0
8
16
24
8
% K
% Leu:
0
8
16
8
0
0
0
0
0
0
0
24
0
47
8
% L
% Met:
0
0
16
0
0
0
0
0
0
0
0
0
0
0
24
% M
% Asn:
0
0
16
0
54
16
0
0
0
8
0
0
0
0
8
% N
% Pro:
0
0
0
16
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
8
0
0
0
0
0
8
0
0
0
0
0
0
% Q
% Arg:
0
8
0
8
16
0
0
0
0
8
0
16
0
0
0
% R
% Ser:
39
0
8
16
0
39
8
47
39
0
47
8
0
0
0
% S
% Thr:
8
16
0
8
8
24
8
31
0
54
24
0
0
0
0
% T
% Val:
24
0
31
0
0
8
8
0
0
8
8
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
16
0
39
16
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _