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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MSH4 All Species: 11.21
Human Site: S66 Identified Species: 20.56
UniProt: O15457 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15457 NP_002431.2 936 104756 S66 A A G D R S S S S S S L P C P
Chimpanzee Pan troglodytes XP_524742 936 104699 S66 A A G D R S S S S S S L P C P
Rhesus Macaque Macaca mulatta XP_001101368 936 104714 S66 A A G D R S S S S S L P C P A
Dog Lupus familis XP_855503 868 98317 R14 I L I S V S G R S Y F G N K R
Cat Felis silvestris
Mouse Mus musculus Q99MT2 958 106988 D89 S T E G A M A D R S S S S S S
Rat Rattus norvegicus NP_001099947 911 101941 A57 S S P A P A A A P G S S F G N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518846 513 58655
Chicken Gallus gallus XP_422549 814 91812
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_688406 931 103864 S66 I S V C P G S S S D T L P S A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q23405 842 96312
Sea Urchin Strong. purpuratus XP_780878 741 83454
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_193469 792 88996
Baker's Yeast Sacchar. cerevisiae P40965 878 99203 S24 L R S A A N S S N S I S K P S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 97.5 86.6 N.A. 83.4 86 N.A. 47.9 70.5 N.A. 57.7 N.A. N.A. N.A. 26.8 50.4
Protein Similarity: 100 99.7 98.4 89.3 N.A. 88.8 91.1 N.A. 51.7 78.4 N.A. 75.8 N.A. N.A. N.A. 47 65
P-Site Identity: 100 100 66.6 13.3 N.A. 13.3 6.6 N.A. 0 0 N.A. 33.3 N.A. N.A. N.A. 0 0
P-Site Similarity: 100 100 66.6 13.3 N.A. 26.6 40 N.A. 0 0 N.A. 46.6 N.A. N.A. N.A. 0 0
Percent
Protein Identity: N.A. N.A. N.A. 31.9 29.3 N.A.
Protein Similarity: N.A. N.A. N.A. 51.3 50.2 N.A.
P-Site Identity: N.A. N.A. N.A. 0 20 N.A.
P-Site Similarity: N.A. N.A. N.A. 0 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 24 24 0 16 16 8 16 8 0 0 0 0 0 0 16 % A
% Cys: 0 0 0 8 0 0 0 0 0 0 0 0 8 16 0 % C
% Asp: 0 0 0 24 0 0 0 8 0 8 0 0 0 0 0 % D
% Glu: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 8 0 8 0 0 % F
% Gly: 0 0 24 8 0 8 8 0 0 8 0 8 0 8 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 16 0 8 0 0 0 0 0 0 0 8 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 8 8 0 % K
% Leu: 8 8 0 0 0 0 0 0 0 0 8 24 0 0 0 % L
% Met: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 8 0 0 8 0 0 0 8 0 8 % N
% Pro: 0 0 8 0 16 0 0 0 8 0 0 8 24 16 16 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 8 0 0 24 0 0 8 8 0 0 0 0 0 8 % R
% Ser: 16 16 8 8 0 31 39 39 39 39 31 24 8 16 16 % S
% Thr: 0 8 0 0 0 0 0 0 0 0 8 0 0 0 0 % T
% Val: 0 0 8 0 8 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _