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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH4
All Species:
14.24
Human Site:
T725
Identified Species:
26.11
UniProt:
O15457
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15457
NP_002431.2
936
104756
T725
Q
I
F
T
R
I
S
T
D
D
D
I
E
T
N
Chimpanzee
Pan troglodytes
XP_524742
936
104699
T725
Q
I
F
T
R
I
S
T
D
D
D
I
E
T
N
Rhesus Macaque
Macaca mulatta
XP_001101368
936
104714
T725
Q
I
F
T
R
L
S
T
D
D
D
I
E
T
N
Dog
Lupus familis
XP_855503
868
98317
D659
F
T
R
I
S
T
D
D
D
I
E
T
N
S
S
Cat
Felis silvestris
Mouse
Mus musculus
Q99MT2
958
106988
T747
Q
I
F
T
R
I
S
T
D
D
D
I
E
T
N
Rat
Rattus norvegicus
NP_001099947
911
101941
D702
F
T
R
I
S
T
D
D
D
I
E
T
N
S
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518846
513
58655
M304
Q
I
F
T
R
I
S
M
D
D
D
I
E
T
N
Chicken
Gallus gallus
XP_422549
814
91812
G605
E
Q
I
F
T
R
I
G
M
D
D
D
I
E
T
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_688406
931
103864
V717
Q
I
F
T
R
I
G
V
D
D
D
F
E
T
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23405
842
96312
H633
R
I
F
S
R
M
G
H
N
D
E
L
I
R
N
Sea Urchin
Strong. purpuratus
XP_780878
741
83454
S532
G
P
N
M
S
G
K
S
T
Y
L
K
Q
I
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_193469
792
88996
F583
G
C
Y
V
P
A
R
F
A
T
I
R
V
V
D
Baker's Yeast
Sacchar. cerevisiae
P40965
878
99203
V669
A
L
Y
G
S
F
P
V
F
K
R
L
H
A
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
97.5
86.6
N.A.
83.4
86
N.A.
47.9
70.5
N.A.
57.7
N.A.
N.A.
N.A.
26.8
50.4
Protein Similarity:
100
99.7
98.4
89.3
N.A.
88.8
91.1
N.A.
51.7
78.4
N.A.
75.8
N.A.
N.A.
N.A.
47
65
P-Site Identity:
100
100
93.3
6.6
N.A.
100
6.6
N.A.
93.3
13.3
N.A.
80
N.A.
N.A.
N.A.
33.3
0
P-Site Similarity:
100
100
100
26.6
N.A.
100
26.6
N.A.
93.3
20
N.A.
80
N.A.
N.A.
N.A.
73.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
31.9
29.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
51.3
50.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
8
0
0
8
0
0
0
0
8
8
% A
% Cys:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
16
16
62
62
54
8
0
0
8
% D
% Glu:
8
0
0
0
0
0
0
0
0
0
24
0
47
8
0
% E
% Phe:
16
0
54
8
0
8
0
8
8
0
0
8
0
0
0
% F
% Gly:
16
0
0
8
0
8
16
8
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
8
0
0
0
0
8
0
0
% H
% Ile:
0
54
8
16
0
39
8
0
0
16
8
39
16
8
0
% I
% Lys:
0
0
0
0
0
0
8
0
0
8
0
8
0
0
0
% K
% Leu:
0
8
0
0
0
8
0
0
0
0
8
16
0
0
0
% L
% Met:
0
0
0
8
0
8
0
8
8
0
0
0
0
0
0
% M
% Asn:
0
0
8
0
0
0
0
0
8
0
0
0
16
0
54
% N
% Pro:
0
8
0
0
8
0
8
0
0
0
0
0
0
0
0
% P
% Gln:
47
8
0
0
0
0
0
0
0
0
0
0
8
0
0
% Q
% Arg:
8
0
16
0
54
8
8
0
0
0
8
8
0
8
8
% R
% Ser:
0
0
0
8
31
0
39
8
0
0
0
0
0
16
16
% S
% Thr:
0
16
0
47
8
16
0
31
8
8
0
16
0
47
8
% T
% Val:
0
0
0
8
0
0
0
16
0
0
0
0
8
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
16
0
0
0
0
0
0
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _