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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH4
All Species:
15.45
Human Site:
Y450
Identified Species:
28.33
UniProt:
O15457
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15457
NP_002431.2
936
104756
Y450
T
P
L
L
R
A
Y
Y
G
S
L
E
D
K
R
Chimpanzee
Pan troglodytes
XP_524742
936
104699
Y450
T
P
L
L
R
A
Y
Y
G
S
L
E
D
K
R
Rhesus Macaque
Macaca mulatta
XP_001101368
936
104714
Y450
T
P
L
L
R
A
Y
Y
G
S
L
E
D
K
R
Dog
Lupus familis
XP_855503
868
98317
S384
L
L
R
A
Y
C
G
S
L
E
D
K
R
F
G
Cat
Felis silvestris
Mouse
Mus musculus
Q99MT2
958
106988
Y472
T
P
L
L
R
A
Y
Y
G
S
L
E
D
H
R
Rat
Rattus norvegicus
NP_001099947
911
101941
S427
L
L
R
A
Y
Y
G
S
L
E
D
H
R
F
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518846
513
58655
R29
K
E
L
L
N
R
D
R
H
P
I
T
K
K
R
Chicken
Gallus gallus
XP_422549
814
91812
Y330
N
T
S
L
L
R
A
Y
Y
N
A
L
E
D
R
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_688406
931
103864
C442
T
H
L
L
T
A
Y
C
K
S
L
E
D
C
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23405
842
96312
F358
I
L
I
E
K
T
E
F
L
K
D
P
R
F
D
Sea Urchin
Strong. purpuratus
XP_780878
741
83454
S257
P
K
E
E
S
V
K
S
S
E
Q
K
I
T
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_193469
792
88996
K308
P
I
L
A
K
V
L
K
D
A
K
C
F
L
L
Baker's Yeast
Sacchar. cerevisiae
P40965
878
99203
L394
K
D
A
L
N
D
Q
L
I
Q
S
R
L
I
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
97.5
86.6
N.A.
83.4
86
N.A.
47.9
70.5
N.A.
57.7
N.A.
N.A.
N.A.
26.8
50.4
Protein Similarity:
100
99.7
98.4
89.3
N.A.
88.8
91.1
N.A.
51.7
78.4
N.A.
75.8
N.A.
N.A.
N.A.
47
65
P-Site Identity:
100
100
100
0
N.A.
93.3
0
N.A.
26.6
20
N.A.
66.6
N.A.
N.A.
N.A.
0
0
P-Site Similarity:
100
100
100
6.6
N.A.
93.3
0
N.A.
33.3
33.3
N.A.
66.6
N.A.
N.A.
N.A.
20
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
31.9
29.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
51.3
50.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
24
0
39
8
0
0
8
8
0
0
0
0
% A
% Cys:
0
0
0
0
0
8
0
8
0
0
0
8
0
8
0
% C
% Asp:
0
8
0
0
0
8
8
0
8
0
24
0
39
8
8
% D
% Glu:
0
8
8
16
0
0
8
0
0
24
0
39
8
0
0
% E
% Phe:
0
0
0
0
0
0
0
8
0
0
0
0
8
24
0
% F
% Gly:
0
0
0
0
0
0
16
0
31
0
0
0
0
0
16
% G
% His:
0
8
0
0
0
0
0
0
8
0
0
8
0
8
0
% H
% Ile:
8
8
8
0
0
0
0
0
8
0
8
0
8
8
0
% I
% Lys:
16
8
0
0
16
0
8
8
8
8
8
16
8
31
0
% K
% Leu:
16
24
54
62
8
0
8
8
24
0
39
8
8
8
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
0
0
16
0
0
0
0
8
0
0
0
0
8
% N
% Pro:
16
31
0
0
0
0
0
0
0
8
0
8
0
0
0
% P
% Gln:
0
0
0
0
0
0
8
0
0
8
8
0
0
0
0
% Q
% Arg:
0
0
16
0
31
16
0
8
0
0
0
8
24
0
54
% R
% Ser:
0
0
8
0
8
0
0
24
8
39
8
0
0
0
8
% S
% Thr:
39
8
0
0
8
8
0
0
0
0
0
8
0
8
0
% T
% Val:
0
0
0
0
0
16
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
16
8
39
39
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _