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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH4
All Species:
18.18
Human Site:
Y589
Identified Species:
33.33
UniProt:
O15457
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15457
NP_002431.2
936
104756
Y589
Q
E
S
L
R
E
I
Y
H
M
T
Y
M
I
V
Chimpanzee
Pan troglodytes
XP_524742
936
104699
Y589
Q
E
S
L
R
E
I
Y
H
M
T
Y
M
I
V
Rhesus Macaque
Macaca mulatta
XP_001101368
936
104714
Y589
Q
E
S
L
R
E
I
Y
H
M
T
Y
M
I
V
Dog
Lupus familis
XP_855503
868
98317
M523
S
L
R
E
I
Y
H
M
T
Y
M
I
V
C
K
Cat
Felis silvestris
Mouse
Mus musculus
Q99MT2
958
106988
Y611
Q
E
S
L
R
E
I
Y
H
M
T
Y
M
I
V
Rat
Rattus norvegicus
NP_001099947
911
101941
M566
S
L
R
E
I
Y
H
M
T
Y
M
I
V
C
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518846
513
58655
Y168
Q
E
S
L
R
E
I
Y
H
M
T
Y
M
I
V
Chicken
Gallus gallus
XP_422549
814
91812
I469
C
Q
E
S
L
R
E
I
Y
H
M
T
Y
L
I
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_688406
931
103864
F581
E
E
A
L
K
D
I
F
H
M
S
Y
V
V
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23405
842
96312
F497
E
Q
V
V
A
E
M
F
L
A
S
D
V
I
V
Sea Urchin
Strong. purpuratus
XP_780878
741
83454
E396
G
K
Y
S
I
P
V
E
S
L
P
P
V
F
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_193469
792
88996
V447
L
E
L
A
S
L
N
V
R
N
K
S
A
A
G
Baker's Yeast
Sacchar. cerevisiae
P40965
878
99203
A533
L
N
I
I
K
K
N
A
R
L
K
E
V
M
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
97.5
86.6
N.A.
83.4
86
N.A.
47.9
70.5
N.A.
57.7
N.A.
N.A.
N.A.
26.8
50.4
Protein Similarity:
100
99.7
98.4
89.3
N.A.
88.8
91.1
N.A.
51.7
78.4
N.A.
75.8
N.A.
N.A.
N.A.
47
65
P-Site Identity:
100
100
100
0
N.A.
100
0
N.A.
100
0
N.A.
46.6
N.A.
N.A.
N.A.
20
0
P-Site Similarity:
100
100
100
6.6
N.A.
100
6.6
N.A.
100
26.6
N.A.
100
N.A.
N.A.
N.A.
66.6
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
31.9
29.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
51.3
50.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
8
8
0
0
8
0
8
0
0
8
8
0
% A
% Cys:
8
0
0
0
0
0
0
0
0
0
0
0
0
16
0
% C
% Asp:
0
0
0
0
0
8
0
0
0
0
0
8
0
0
0
% D
% Glu:
16
54
8
16
0
47
8
8
0
0
0
8
0
0
8
% E
% Phe:
0
0
0
0
0
0
0
16
0
0
0
0
0
8
0
% F
% Gly:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% G
% His:
0
0
0
0
0
0
16
0
47
8
0
0
0
0
0
% H
% Ile:
0
0
8
8
24
0
47
8
0
0
0
16
0
47
16
% I
% Lys:
0
8
0
0
16
8
0
0
0
0
16
0
0
0
16
% K
% Leu:
16
16
8
47
8
8
0
0
8
16
0
0
0
8
0
% L
% Met:
0
0
0
0
0
0
8
16
0
47
24
0
39
8
0
% M
% Asn:
0
8
0
0
0
0
16
0
0
8
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
8
0
0
0
0
8
8
0
0
0
% P
% Gln:
39
16
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
16
0
39
8
0
0
16
0
0
0
0
0
0
% R
% Ser:
16
0
39
16
8
0
0
0
8
0
16
8
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
16
0
39
8
0
0
0
% T
% Val:
0
0
8
8
0
0
8
8
0
0
0
0
47
8
54
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
16
0
39
8
16
0
47
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _