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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
INSIG1
All Species:
13.64
Human Site:
Y236
Identified Species:
30
UniProt:
O15503
Number Species:
10
Phosphosite Substitution
Charge Score:
0.5
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15503
NP_005533.2
277
29987
Y236
V
Y
N
G
V
Y
Q
Y
T
S
P
D
F
L
Y
Chimpanzee
Pan troglodytes
XP_001145487
277
30007
Y236
V
Y
N
G
V
Y
Q
Y
T
S
P
D
F
L
Y
Rhesus Macaque
Macaca mulatta
XP_001111307
284
31535
V247
K
N
R
S
N
Y
K
V
F
L
K
S
P
I
V
Dog
Lupus familis
XP_850396
273
28967
Y232
V
Y
N
G
V
Y
Q
Y
T
S
P
D
F
L
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q8BGI3
259
28194
D222
V
Y
Q
Y
T
S
P
D
F
L
Y
I
R
S
W
Rat
Rattus norvegicus
Q08755
259
28213
D222
V
Y
Q
Y
T
S
P
D
F
L
Y
I
R
S
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512717
273
29878
Y232
V
Y
N
G
V
Y
Q
Y
T
S
P
D
F
L
Y
Chicken
Gallus gallus
Q5ZMT9
252
27336
D215
V
Y
Q
Y
T
S
P
D
F
L
Y
I
R
S
W
Frog
Xenopus laevis
Q6DF80
251
27551
D214
V
Y
Q
Y
T
S
P
D
F
L
Y
I
R
S
W
Zebra Danio
Brachydanio rerio
Q8AV61
251
27578
D214
I
Y
Q
Y
T
S
P
D
F
L
Y
V
R
S
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001201451
248
27492
L211
R
Y
T
E
P
D
F
L
Y
V
R
S
W
L
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
58.7
84.1
N.A.
79.4
80.1
N.A.
81.9
77.6
75
70.4
N.A.
N.A.
N.A.
N.A.
54.8
Protein Similarity:
100
99.6
61.9
87
N.A.
83.3
84.1
N.A.
86.6
80.8
80.5
79.7
N.A.
N.A.
N.A.
N.A.
66
P-Site Identity:
100
100
6.6
100
N.A.
13.3
13.3
N.A.
100
13.3
13.3
6.6
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
100
20
100
N.A.
20
20
N.A.
100
20
20
20
N.A.
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
10
0
46
0
0
0
37
0
0
0
% D
% Glu:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
10
0
55
0
0
0
37
0
0
% F
% Gly:
0
0
0
37
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
10
0
0
0
0
0
0
0
0
0
0
37
0
10
0
% I
% Lys:
10
0
0
0
0
0
10
0
0
0
10
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
10
0
55
0
0
0
46
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
10
37
0
10
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
10
0
46
0
0
0
37
0
10
0
10
% P
% Gln:
0
0
46
0
0
0
37
0
0
0
0
0
0
0
0
% Q
% Arg:
10
0
10
0
0
0
0
0
0
0
10
0
46
0
0
% R
% Ser:
0
0
0
10
0
46
0
0
0
37
0
19
0
46
0
% S
% Thr:
0
0
10
0
46
0
0
0
37
0
0
0
0
0
0
% T
% Val:
73
0
0
0
37
0
0
10
0
10
0
10
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
46
% W
% Tyr:
0
91
0
46
0
46
0
37
10
0
46
0
0
0
37
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _