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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POLR2D All Species: 25.76
Human Site: T107 Identified Species: 51.52
UniProt: O15514 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15514 NP_004796.1 142 16311 T107 L A N L C P E T A E E S K A L
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001090528 142 16263 T107 L A N L C P E T A E E S K A L
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus NP_081377 104 12248 K74 P E T A E E S K A L I P S L E
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517684 133 15350 E101 L C P E T A E E A K A L I P S
Chicken Gallus gallus XP_422576 142 16307 T107 L A N L C P E T A E E A K A L
Frog Xenopus laevis NP_001087315 142 16276 T107 L A N L C P E T A D E A K A L
Zebra Danio Brachydanio rerio NP_001002317 141 16149 A106 L A N L C P E A A E E A K A L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VEA5 139 16194 A104 L G N L C P E A P E E A K A L
Honey Bee Apis mellifera XP_391932 580 67411 T545 L A N L C P E T P E E A K A L
Nematode Worm Caenorhab. elegans NP_495544 144 16511 N110 I A N L C P E N A E E A K A L
Sea Urchin Strong. purpuratus XP_795859 142 16580 T107 L A N L C P E T A E E A K A L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P20433 221 25396 T187 L G S L A C D T A D E A K T L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 99.3 N.A. N.A. 73.2 N.A. N.A. 85.2 97.1 90.8 92.2 N.A. 72.5 21 57.6 76
Protein Similarity: 100 N.A. 99.3 N.A. N.A. 73.2 N.A. N.A. 87.3 98.5 97.8 95 N.A. 81.6 22.5 81.2 84.5
P-Site Identity: 100 N.A. 100 N.A. N.A. 6.6 N.A. N.A. 20 93.3 86.6 86.6 N.A. 73.3 86.6 80 93.3
P-Site Similarity: 100 N.A. 100 N.A. N.A. 6.6 N.A. N.A. 26.6 100 100 93.3 N.A. 80 93.3 93.3 100
Percent
Protein Identity: N.A. N.A. N.A. N.A. 30.3 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 43.4 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 46.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 73.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 67 0 9 9 9 0 17 84 0 9 67 0 75 0 % A
% Cys: 0 9 0 0 75 9 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 9 0 0 17 0 0 0 0 0 % D
% Glu: 0 9 0 9 9 9 84 9 0 67 84 0 0 0 9 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 17 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 9 0 0 0 0 0 0 0 0 0 9 0 9 0 0 % I
% Lys: 0 0 0 0 0 0 0 9 0 9 0 0 84 0 0 % K
% Leu: 84 0 0 84 0 0 0 0 0 9 0 9 0 9 84 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 75 0 0 0 0 9 0 0 0 0 0 0 0 % N
% Pro: 9 0 9 0 0 75 0 0 17 0 0 9 0 9 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 9 0 0 0 9 0 0 0 0 17 9 0 9 % S
% Thr: 0 0 9 0 9 0 0 59 0 0 0 0 0 9 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _