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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CLOCK All Species: 22.73
Human Site: S153 Identified Species: 45.45
UniProt: O15516 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15516 NP_004889.1 846 95304 S153 P S D L V D Q S I F N F I P E
Chimpanzee Pan troglodytes XP_001143582 847 95413 S153 P S D L V D Q S I F N F I P E
Rhesus Macaque Macaca mulatta XP_001105763 824 91854 V151 I L S S H M L V T D S P S P E
Dog Lupus familis XP_532376 837 94069 N147 L V D Q S I F N F I P E G E H
Cat Felis silvestris
Mouse Mus musculus O08785 855 96374 S153 P S D L V D Q S I F N F I P E
Rat Rattus norvegicus Q9WVS9 862 96985 S153 P S D L V D Q S I F N F I P E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507170 847 93368 S170 P S D L V D Q S I F N F I P E
Chicken Gallus gallus Q8QGQ6 875 98641 S153 P S D L V D Q S V F N F I P E
Frog Xenopus laevis NP_001083854 825 93251 N147 L V D Q S I F N F V P E G E H
Zebra Danio Brachydanio rerio NP_571032 893 100927 N147 L V D Q N L L N F L P L G E H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O61735 1027 116123 L147 Y E M D H E A L L N I F M N P
Honey Bee Apis mellifera XP_394233 708 81000 V50 R K M D K S T V L K S T I L F
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 49.8 96.2 N.A. 95 93.1 N.A. 80.6 84.6 78.1 68.1 N.A. 30.9 37.5 N.A. N.A.
Protein Similarity: 100 99.8 65 97.2 N.A. 96.1 94.7 N.A. 85.8 89.4 86.1 77 N.A. 48.8 52.7 N.A. N.A.
P-Site Identity: 100 100 13.3 6.6 N.A. 100 100 N.A. 100 93.3 6.6 6.6 N.A. 6.6 6.6 N.A. N.A.
P-Site Similarity: 100 100 20 13.3 N.A. 100 100 N.A. 100 100 13.3 13.3 N.A. 26.6 20 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 75 17 0 50 0 0 0 9 0 0 0 0 0 % D
% Glu: 0 9 0 0 0 9 0 0 0 0 0 17 0 25 59 % E
% Phe: 0 0 0 0 0 0 17 0 25 50 0 59 0 0 9 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 25 0 0 % G
% His: 0 0 0 0 17 0 0 0 0 0 0 0 0 0 25 % H
% Ile: 9 0 0 0 0 17 0 0 42 9 9 0 59 0 0 % I
% Lys: 0 9 0 0 9 0 0 0 0 9 0 0 0 0 0 % K
% Leu: 25 9 0 50 0 9 17 9 17 9 0 9 0 9 0 % L
% Met: 0 0 17 0 0 9 0 0 0 0 0 0 9 0 0 % M
% Asn: 0 0 0 0 9 0 0 25 0 9 50 0 0 9 0 % N
% Pro: 50 0 0 0 0 0 0 0 0 0 25 9 0 59 9 % P
% Gln: 0 0 0 25 0 0 50 0 0 0 0 0 0 0 0 % Q
% Arg: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 50 9 9 17 9 0 50 0 0 17 0 9 0 0 % S
% Thr: 0 0 0 0 0 0 9 0 9 0 0 9 0 0 0 % T
% Val: 0 25 0 0 50 0 0 17 9 9 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _