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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CLOCK
All Species:
21.82
Human Site:
S221
Identified Species:
43.64
UniProt:
O15516
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15516
NP_004889.1
846
95304
S221
K
F
I
G
N
F
K
S
L
N
S
V
S
S
S
Chimpanzee
Pan troglodytes
XP_001143582
847
95413
S221
K
F
I
G
N
F
K
S
L
N
S
V
S
S
S
Rhesus Macaque
Macaca mulatta
XP_001105763
824
91854
P219
L
S
R
P
C
R
V
P
L
G
K
E
V
C
F
Dog
Lupus familis
XP_532376
837
94069
S215
G
N
F
K
S
L
N
S
V
S
T
S
A
H
N
Cat
Felis silvestris
Mouse
Mus musculus
O08785
855
96374
S221
R
F
I
G
N
F
K
S
L
T
S
V
S
T
S
Rat
Rattus norvegicus
Q9WVS9
862
96985
S221
R
F
I
G
N
F
K
S
L
N
S
V
S
T
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507170
847
93368
S238
K
F
I
G
N
F
K
S
L
N
S
V
S
S
S
Chicken
Gallus gallus
Q8QGQ6
875
98641
C221
K
F
I
G
N
F
K
C
L
N
N
V
P
N
S
Frog
Xenopus laevis
NP_001083854
825
93251
N215
G
N
F
K
S
L
N
N
V
P
N
S
T
H
N
Zebra Danio
Brachydanio rerio
NP_571032
893
100927
T215
G
N
F
K
S
L
N
T
V
P
N
S
T
R
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O61735
1027
116123
N215
G
S
S
S
E
V
S
N
G
S
N
G
Q
P
A
Honey Bee
Apis mellifera
XP_394233
708
81000
L118
V
S
E
S
V
T
S
L
L
G
Y
L
P
N
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
49.8
96.2
N.A.
95
93.1
N.A.
80.6
84.6
78.1
68.1
N.A.
30.9
37.5
N.A.
N.A.
Protein Similarity:
100
99.8
65
97.2
N.A.
96.1
94.7
N.A.
85.8
89.4
86.1
77
N.A.
48.8
52.7
N.A.
N.A.
P-Site Identity:
100
100
6.6
6.6
N.A.
80
86.6
N.A.
100
73.3
0
0
N.A.
0
6.6
N.A.
N.A.
P-Site Similarity:
100
100
6.6
46.6
N.A.
93.3
100
N.A.
100
86.6
40
40
N.A.
26.6
20
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
9
% A
% Cys:
0
0
0
0
9
0
0
9
0
0
0
0
0
9
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
9
0
9
0
0
0
0
0
0
9
0
0
9
% E
% Phe:
0
50
25
0
0
50
0
0
0
0
0
0
0
0
9
% F
% Gly:
34
0
0
50
0
0
0
0
9
17
0
9
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
17
0
% H
% Ile:
0
0
50
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
34
0
0
25
0
0
50
0
0
0
9
0
0
0
0
% K
% Leu:
9
0
0
0
0
25
0
9
67
0
0
9
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
25
0
0
50
0
25
17
0
42
34
0
0
17
25
% N
% Pro:
0
0
0
9
0
0
0
9
0
17
0
0
17
9
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% Q
% Arg:
17
0
9
0
0
9
0
0
0
0
0
0
0
9
0
% R
% Ser:
0
25
9
17
25
0
17
50
0
17
42
25
42
25
50
% S
% Thr:
0
0
0
0
0
9
0
9
0
9
9
0
17
17
0
% T
% Val:
9
0
0
0
9
9
9
0
25
0
0
50
9
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _