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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NKX2-8
All Species:
17.27
Human Site:
S66
Identified Species:
38
UniProt:
O15522
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15522
NP_055175.2
239
25866
S66
L
E
T
S
P
P
D
S
S
Q
R
P
S
A
R
Chimpanzee
Pan troglodytes
XP_522995
239
25933
S66
L
E
T
S
P
P
D
S
S
Q
R
P
S
A
R
Rhesus Macaque
Macaca mulatta
XP_001085187
509
55398
S339
L
E
T
S
P
P
D
S
S
Q
R
P
S
V
M
Dog
Lupus familis
XP_852202
239
25987
S66
P
E
T
S
P
P
D
S
S
Q
R
P
S
A
R
Cat
Felis silvestris
Mouse
Mus musculus
O70584
235
26115
S63
L
E
T
S
P
A
D
S
S
Q
L
A
S
L
R
Rat
Rattus norvegicus
P23441
372
38536
L143
N
M
S
G
M
G
G
L
G
S
L
G
D
V
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90788
294
33054
L101
L
C
A
L
H
K
S
L
E
Q
E
K
R
E
L
Frog
Xenopus laevis
P42587
196
22791
S49
L
L
S
L
Q
K
P
S
A
D
E
S
P
D
N
Zebra Danio
Brachydanio rerio
Q90481
269
30288
E107
S
P
E
P
S
A
D
E
S
P
D
N
D
K
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P22808
723
76404
A527
D
I
D
D
V
D
D
A
D
G
S
G
G
G
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P41936
346
37493
I171
K
L
E
D
E
D
E
I
L
E
D
E
E
N
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
42.2
87.8
N.A.
74.9
31.9
N.A.
N.A.
28.9
41
42
N.A.
20.6
N.A.
26.8
N.A.
Protein Similarity:
100
99.5
43.6
90.3
N.A.
79.9
41.4
N.A.
N.A.
42.1
51
53.5
N.A.
23.3
N.A.
36.9
N.A.
P-Site Identity:
100
100
86.6
93.3
N.A.
73.3
0
N.A.
N.A.
13.3
13.3
13.3
N.A.
6.6
N.A.
0
N.A.
P-Site Similarity:
100
100
86.6
93.3
N.A.
73.3
6.6
N.A.
N.A.
13.3
26.6
13.3
N.A.
13.3
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
0
0
19
0
10
10
0
0
10
0
28
0
% A
% Cys:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
10
19
0
19
64
0
10
10
19
0
19
10
19
% D
% Glu:
0
46
19
0
10
0
10
10
10
10
19
10
10
10
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
10
0
10
10
0
10
10
0
19
10
10
0
% G
% His:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
10
0
0
0
0
0
10
0
0
0
0
0
0
0
% I
% Lys:
10
0
0
0
0
19
0
0
0
0
0
10
0
10
0
% K
% Leu:
55
19
0
19
0
0
0
19
10
0
19
0
0
10
10
% L
% Met:
0
10
0
0
10
0
0
0
0
0
0
0
0
0
10
% M
% Asn:
10
0
0
0
0
0
0
0
0
0
0
10
0
10
10
% N
% Pro:
10
10
0
10
46
37
10
0
0
10
0
37
10
0
0
% P
% Gln:
0
0
0
0
10
0
0
0
0
55
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
37
0
10
0
37
% R
% Ser:
10
0
19
46
10
0
10
55
55
10
10
10
46
0
10
% S
% Thr:
0
0
46
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
10
0
0
0
0
0
0
0
0
19
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _