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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CYP27B1 All Species: 30.61
Human Site: T218 Identified Species: 74.81
UniProt: O15528 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15528 NP_000776.1 508 56504 T218 E A Q V P P D T E T F I R A V
Chimpanzee Pan troglodytes XP_509175 508 56515 T218 E A Q V P P D T E T F I R A V
Rhesus Macaque Macaca mulatta XP_001116450 508 56650 T218 E A Q V P P D T E T F I R A V
Dog Lupus familis XP_538254 535 58293 T245 E A Q V P P D T D A F I R A V
Cat Felis silvestris
Mouse Mus musculus O35084 507 56206 T218 E A E V P P D T E T F I H A V
Rat Rattus norvegicus O35132 501 55350 T211 E A E V P P D T E T F I E A V
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_422077 536 61257 T245 E N N V P Q Q T V E Y I E A L
Frog Xenopus laevis NP_001087098 542 61748 T251 E K Q T P P E T Q K F I D S I
Zebra Danio Brachydanio rerio NP_001116749 513 58741 T226 N D E I P E E T Q K F I F S V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9V5L3 589 65883 A291 S P E G S E E A Q Q I I E A I
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 96.2 83.9 N.A. 81.5 81.5 N.A. N.A. 41.4 38.1 40.7 N.A. 27.3 N.A. N.A. N.A.
Protein Similarity: 100 99.6 97.4 87.6 N.A. 88.5 89.3 N.A. N.A. 58.9 57.9 62.7 N.A. 42.2 N.A. N.A. N.A.
P-Site Identity: 100 100 100 86.6 N.A. 86.6 86.6 N.A. N.A. 40 46.6 33.3 N.A. 13.3 N.A. N.A. N.A.
P-Site Similarity: 100 100 100 93.3 N.A. 93.3 93.3 N.A. N.A. 53.3 73.3 66.6 N.A. 40 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 60 0 0 0 0 0 10 0 10 0 0 0 80 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 10 0 0 0 0 60 0 10 0 0 0 10 0 0 % D
% Glu: 80 0 40 0 0 20 30 0 50 10 0 0 30 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 80 0 10 0 0 % F
% Gly: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % H
% Ile: 0 0 0 10 0 0 0 0 0 0 10 100 0 0 20 % I
% Lys: 0 10 0 0 0 0 0 0 0 20 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 10 10 10 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 10 0 0 90 70 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 50 0 0 10 10 0 30 10 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 40 0 0 % R
% Ser: 10 0 0 0 10 0 0 0 0 0 0 0 0 20 0 % S
% Thr: 0 0 0 10 0 0 0 90 0 50 0 0 0 0 0 % T
% Val: 0 0 0 70 0 0 0 0 10 0 0 0 0 0 70 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _