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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
P2RX6
All Species:
7.88
Human Site:
S408
Identified Species:
19.26
UniProt:
O15547
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15547
NP_001153026.1
431
47913
S408
P
T
A
T
A
A
G
S
Q
T
Q
T
P
G
W
Chimpanzee
Pan troglodytes
XP_001168351
441
48812
S418
P
M
A
T
A
A
G
S
Q
T
Q
T
P
G
W
Rhesus Macaque
Macaca mulatta
XP_001084368
438
48443
A416
P
A
P
T
A
T
A
A
G
S
Q
T
Q
T
P
Dog
Lupus familis
XP_543562
527
57557
S505
G
V
L
E
G
T
Q
S
G
N
Q
T
P
T
A
Cat
Felis silvestris
Mouse
Mus musculus
O54803
379
42097
E357
L
L
L
Y
V
D
R
E
A
G
F
Y
W
R
T
Rat
Rattus norvegicus
P51579
379
42432
E357
L
L
L
Y
V
D
R
E
A
G
F
Y
W
R
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514747
385
42456
S363
D
G
E
A
A
F
Y
S
G
V
K
Y
E
E
A
Chicken
Gallus gallus
NP_990079
402
45138
S380
K
Y
E
E
V
K
S
S
S
R
K
S
L
T
S
Frog
Xenopus laevis
NP_001082067
391
44317
R369
F
K
K
R
H
Y
Y
R
E
K
K
Y
K
Y
V
Zebra Danio
Brachydanio rerio
NP_919394
481
54639
T415
H
R
R
E
E
K
P
T
A
E
M
Q
P
L
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96.8
92.4
63.1
N.A.
72.8
70.3
N.A.
59.1
48.2
39.9
42.6
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
97
94.9
68.6
N.A.
77.7
77.2
N.A.
68.9
64
58.4
56.1
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
93.3
33.3
26.6
N.A.
0
0
N.A.
13.3
6.6
0
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
93.3
46.6
26.6
N.A.
0
0
N.A.
20
20
13.3
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
20
10
40
20
10
10
30
0
0
0
0
0
20
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
0
0
0
20
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
20
30
10
0
0
20
10
10
0
0
10
10
0
% E
% Phe:
10
0
0
0
0
10
0
0
0
0
20
0
0
0
0
% F
% Gly:
10
10
0
0
10
0
20
0
30
20
0
0
0
20
0
% G
% His:
10
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
10
10
10
0
0
20
0
0
0
10
30
0
10
0
0
% K
% Leu:
20
20
30
0
0
0
0
0
0
0
0
0
10
10
0
% L
% Met:
0
10
0
0
0
0
0
0
0
0
10
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% N
% Pro:
30
0
10
0
0
0
10
0
0
0
0
0
40
0
10
% P
% Gln:
0
0
0
0
0
0
10
0
20
0
40
10
10
0
0
% Q
% Arg:
0
10
10
10
0
0
20
10
0
10
0
0
0
20
0
% R
% Ser:
0
0
0
0
0
0
10
50
10
10
0
10
0
0
10
% S
% Thr:
0
10
0
30
0
20
0
10
0
20
0
40
0
30
30
% T
% Val:
0
10
0
0
30
0
0
0
0
10
0
0
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
20
0
20
% W
% Tyr:
0
10
0
20
0
10
20
0
0
0
0
40
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _