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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CLDN3 All Species: 17.27
Human Site: S199 Identified Species: 42.22
UniProt: O15551 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15551 NP_001297.1 220 23319 S199 T A T K V V Y S A P R S T G P
Chimpanzee Pan troglodytes XP_001147969 220 23254 S199 T A T K V V Y S A P R S T G P
Rhesus Macaque Macaca mulatta XP_001112442 220 23463 S199 M P T K V V Y S A P R S T G P
Dog Lupus familis XP_546920 210 22073 C185 G A L L C C N C P P R A D K P
Cat Felis silvestris
Mouse Mus musculus Q9Z0G9 219 23266 S198 A P T K I L Y S A P R S T G P
Rat Rattus norvegicus Q63400 219 23296 S198 A P T K I L Y S A P R S T G P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509958 214 22761 P193 P K D K K Y V P A K V M Y S A
Chicken Gallus gallus NP_989533 214 23072 P193 P K D E R Y A P S K V A Y S A
Frog Xenopus laevis NP_001087400 213 22866 S193 P K D K Y P P S R V A Y T A A
Zebra Danio Brachydanio rerio Q9YH91 208 22187 Q184 G G A L L C C Q C P K N E G R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 93.1 95.9 71.8 N.A. 90.9 90.4 N.A. 80.4 74 70.4 60 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 93.1 97.2 83.6 N.A. 95.4 95 N.A. 90.9 89 89.5 76.8 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 86.6 26.6 N.A. 73.3 73.3 N.A. 13.3 0 20 13.3 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 86.6 33.3 N.A. 86.6 86.6 N.A. 13.3 20 20 33.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 20 30 10 0 0 0 10 0 60 0 10 20 0 10 30 % A
% Cys: 0 0 0 0 10 20 10 10 10 0 0 0 0 0 0 % C
% Asp: 0 0 30 0 0 0 0 0 0 0 0 0 10 0 0 % D
% Glu: 0 0 0 10 0 0 0 0 0 0 0 0 10 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 20 10 0 0 0 0 0 0 0 0 0 0 0 60 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 20 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 30 0 70 10 0 0 0 0 20 10 0 0 10 0 % K
% Leu: 0 0 10 20 10 20 0 0 0 0 0 0 0 0 0 % L
% Met: 10 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % M
% Asn: 0 0 0 0 0 0 10 0 0 0 0 10 0 0 0 % N
% Pro: 30 30 0 0 0 10 10 20 10 70 0 0 0 0 60 % P
% Gln: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 10 0 0 0 10 0 60 0 0 0 10 % R
% Ser: 0 0 0 0 0 0 0 60 10 0 0 50 0 20 0 % S
% Thr: 20 0 50 0 0 0 0 0 0 0 0 0 60 0 0 % T
% Val: 0 0 0 0 30 30 10 0 0 10 20 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 10 20 50 0 0 0 0 10 20 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _