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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CLDN3
All Species:
24.24
Human Site:
Y219
Identified Species:
59.26
UniProt:
O15551
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15551
NP_001297.1
220
23319
Y219
T
G
Y
D
R
K
D
Y
V
_
_
_
_
_
_
Chimpanzee
Pan troglodytes
XP_001147969
220
23254
Y219
T
G
Y
D
R
K
D
Y
V
_
_
_
_
_
_
Rhesus Macaque
Macaca mulatta
XP_001112442
220
23463
Y219
T
A
Y
D
R
K
D
Y
V
_
_
_
_
_
_
Dog
Lupus familis
XP_546920
210
22073
P205
S
A
A
A
R
S
A
P
A
S
N
Y
V
_
_
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z0G9
219
23266
Y218
T
A
Y
D
R
K
D
Y
V
_
_
_
_
_
_
Rat
Rattus norvegicus
Q63400
219
23296
Y218
T
A
Y
D
R
K
D
Y
V
_
_
_
_
_
_
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509958
214
22761
Y213
P
S
Y
D
R
K
D
Y
V
_
_
_
_
_
_
Chicken
Gallus gallus
NP_989533
214
23072
Y213
T
S
Y
D
K
R
N
Y
V
_
_
_
_
_
_
Frog
Xenopus laevis
NP_001087400
213
22866
Zebra Danio
Brachydanio rerio
Q9YH91
208
22187
P204
Y
S
A
P
R
S
A
P
G
A
Y
V
_
_
_
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93.1
95.9
71.8
N.A.
90.9
90.4
N.A.
80.4
74
70.4
60
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
93.1
97.2
83.6
N.A.
95.4
95
N.A.
90.9
89
89.5
76.8
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
88.8
7.6
N.A.
88.8
88.8
N.A.
77.7
55.5
0
8.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
88.8
23
N.A.
88.8
88.8
N.A.
77.7
88.8
0
16.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
40
20
10
0
0
20
0
10
10
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
70
0
0
60
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
20
0
0
0
0
0
0
10
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
10
60
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
10
0
0
0
10
0
0
0
0
% N
% Pro:
10
0
0
10
0
0
0
20
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
80
10
0
0
0
0
0
0
0
0
0
% R
% Ser:
10
30
0
0
0
20
0
0
0
10
0
0
0
0
0
% S
% Thr:
60
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
70
0
0
10
10
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
70
0
0
0
0
70
0
0
10
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
70
70
70
80
90
90
% _