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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: RNMT All Species: 20.3
Human Site: Y421 Identified Species: 34.36
UniProt: O43148 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O43148 NP_003790.1 476 54844 Y421 R M Q A L E P Y P A N E S S K
Chimpanzee Pan troglodytes XP_001171239 476 54873 Y421 R M Q A L E P Y P A N E S S K
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_533404 460 53118 N407 F Y E E K I K N N E N K M L L
Cat Felis silvestris
Mouse Mus musculus Q9D0L8 465 53273 Y410 R M Q A L E Q Y P A H E N S K
Rat Rattus norvegicus Q5U2U7 461 52798 Y406 R M Q A L E S Y P A N E N S K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519491 604 67589 Y430 R M Q A L E P Y P A N E H S K
Chicken Gallus gallus XP_419132 415 47522 T362 Q A L E P Y S T F G D S R L A
Frog Xenopus laevis Q9I8S2 402 45985 A349 K A L E S Y P A A P N T K L V
Zebra Danio Brachydanio rerio Q1MTD3 400 45942 P347 Q A L E Q Y P P D E R G Q L S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VJQ4 427 48660 F374 R C E N D E E F A H V S N F Q
Honey Bee Apis mellifera XP_395738 367 42655 Y314 K I Q A L E T Y P P R N D V S
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_785441 457 51312 E400 D F E E E E E E E E E E A A P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LHQ7 370 42219 N317 G A L G D G S N D Q S T L S A
Baker's Yeast Sacchar. cerevisiae P32783 436 50322 K382 F F V Q E I P K W I E R F S P
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 N.A. 85.7 N.A. 74.7 76 N.A. 55.2 62.6 59.4 52.7 N.A. 39 38.8 N.A. 46
Protein Similarity: 100 99.3 N.A. 90.1 N.A. 84 84 N.A. 63.7 72 71.8 67.8 N.A. 58.8 54.2 N.A. 61.5
P-Site Identity: 100 100 N.A. 6.6 N.A. 80 86.6 N.A. 93.3 0 13.3 6.6 N.A. 13.3 40 N.A. 13.3
P-Site Similarity: 100 100 N.A. 20 N.A. 93.3 93.3 N.A. 93.3 13.3 20 13.3 N.A. 40 53.3 N.A. 33.3
Percent
Protein Identity: N.A. N.A. N.A. 28.7 29.4 N.A.
Protein Similarity: N.A. N.A. N.A. 43.2 47 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 29 0 43 0 0 0 8 15 36 0 0 8 8 15 % A
% Cys: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 0 0 15 0 0 0 15 0 8 0 8 0 0 % D
% Glu: 0 0 22 36 15 58 15 8 8 22 15 43 0 0 0 % E
% Phe: 15 15 0 0 0 0 0 8 8 0 0 0 8 8 0 % F
% Gly: 8 0 0 8 0 8 0 0 0 8 0 8 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 8 8 0 8 0 0 % H
% Ile: 0 8 0 0 0 15 0 0 0 8 0 0 0 0 0 % I
% Lys: 15 0 0 0 8 0 8 8 0 0 0 8 8 0 36 % K
% Leu: 0 0 29 0 43 0 0 0 0 0 0 0 8 29 8 % L
% Met: 0 36 0 0 0 0 0 0 0 0 0 0 8 0 0 % M
% Asn: 0 0 0 8 0 0 0 15 8 0 43 8 22 0 0 % N
% Pro: 0 0 0 0 8 0 43 8 43 15 0 0 0 0 15 % P
% Gln: 15 0 43 8 8 0 8 0 0 8 0 0 8 0 8 % Q
% Arg: 43 0 0 0 0 0 0 0 0 0 15 8 8 0 0 % R
% Ser: 0 0 0 0 8 0 22 0 0 0 8 15 15 50 15 % S
% Thr: 0 0 0 0 0 0 8 8 0 0 0 15 0 0 0 % T
% Val: 0 0 8 0 0 0 0 0 0 0 8 0 0 8 8 % V
% Trp: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % W
% Tyr: 0 8 0 0 0 22 0 43 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _