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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: RNMT All Species: 18.48
Human Site: Y437 Identified Species: 31.28
UniProt: O43148 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O43148 NP_003790.1 476 54844 Y437 V S E K V D D Y E H A A K Y M
Chimpanzee Pan troglodytes XP_001171239 476 54873 Y437 V S E K V D D Y E H A A K Y M
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_533404 460 53118 Y423 R M Q A L E P Y P A N E N S K
Cat Felis silvestris
Mouse Mus musculus Q9D0L8 465 53273 Y426 A S E K V G D Y T H A A E Y L
Rat Rattus norvegicus Q5U2U7 461 52798 Y422 A S E K A G D Y A H A A E Y M
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519491 604 67589 Y446 V S D N M E D Y E H A V K Y I
Chicken Gallus gallus XP_419132 415 47522 H378 D K P D D Y E H A K E F I K D
Frog Xenopus laevis Q9I8S2 402 45985 H365 G R T E D Y E H A Q K M V E N
Zebra Danio Brachydanio rerio Q1MTD3 400 45942 H363 S G P G E Y D H A K R K A A D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VJQ4 427 48660 G390 A Q R S R S V G T L S K S E W
Honey Bee Apis mellifera XP_395738 367 42655 Q330 V G K P E D Y Q H I K E Y N M
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_785441 457 51312 E416 A E E K K E E E E K T E E V A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LHQ7 370 42219 Y333 E W E A A Y L Y L S F V L R K
Baker's Yeast Sacchar. cerevisiae P32783 436 50322 S398 M R E G L Q R S D G R Y G V E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 N.A. 85.7 N.A. 74.7 76 N.A. 55.2 62.6 59.4 52.7 N.A. 39 38.8 N.A. 46
Protein Similarity: 100 99.3 N.A. 90.1 N.A. 84 84 N.A. 63.7 72 71.8 67.8 N.A. 58.8 54.2 N.A. 61.5
P-Site Identity: 100 100 N.A. 6.6 N.A. 66.6 66.6 N.A. 60 0 0 6.6 N.A. 0 20 N.A. 20
P-Site Similarity: 100 100 N.A. 26.6 N.A. 80 73.3 N.A. 86.6 13.3 20 13.3 N.A. 6.6 26.6 N.A. 40
Percent
Protein Identity: N.A. N.A. N.A. 28.7 29.4 N.A.
Protein Similarity: N.A. N.A. N.A. 43.2 47 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 29 0 0 15 15 0 0 0 29 8 36 29 8 8 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 8 8 15 22 43 0 8 0 0 0 0 0 15 % D
% Glu: 8 8 50 8 15 22 22 8 29 0 8 22 22 15 8 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 8 8 0 0 0 % F
% Gly: 8 15 0 15 0 15 0 8 0 8 0 0 8 0 0 % G
% His: 0 0 0 0 0 0 0 22 8 36 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 8 0 0 8 0 8 % I
% Lys: 0 8 8 36 8 0 0 0 0 22 15 15 22 8 15 % K
% Leu: 0 0 0 0 15 0 8 0 8 8 0 0 8 0 8 % L
% Met: 8 8 0 0 8 0 0 0 0 0 0 8 0 0 29 % M
% Asn: 0 0 0 8 0 0 0 0 0 0 8 0 8 8 8 % N
% Pro: 0 0 15 8 0 0 8 0 8 0 0 0 0 0 0 % P
% Gln: 0 8 8 0 0 8 0 8 0 8 0 0 0 0 0 % Q
% Arg: 8 15 8 0 8 0 8 0 0 0 15 0 0 8 0 % R
% Ser: 8 36 0 8 0 8 0 8 0 8 8 0 8 8 0 % S
% Thr: 0 0 8 0 0 0 0 0 15 0 8 0 0 0 0 % T
% Val: 29 0 0 0 22 0 8 0 0 0 0 15 8 15 0 % V
% Trp: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 8 % W
% Tyr: 0 0 0 0 0 29 8 50 0 0 0 8 8 36 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _