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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: RNMT All Species: 17.27
Human Site: Y443 Identified Species: 29.23
UniProt: O43148 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O43148 NP_003790.1 476 54844 Y443 D Y E H A A K Y M K N S Q V R
Chimpanzee Pan troglodytes XP_001171239 476 54873 Y443 D Y E H A A K Y M K N S Q V R
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_533404 460 53118 S429 P Y P A N E N S K L A S E K V
Cat Felis silvestris
Mouse Mus musculus Q9D0L8 465 53273 Y432 D Y T H A A E Y L K K S Q V R
Rat Rattus norvegicus Q5U2U7 461 52798 Y428 D Y A H A A E Y M K N S Q V R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519491 604 67589 Y452 D Y E H A V K Y I K N G Q T R
Chicken Gallus gallus XP_419132 415 47522 K384 E H A K E F I K D G K A K L P
Frog Xenopus laevis Q9I8S2 402 45985 E371 E H A Q K M V E N G Q I K L P
Zebra Danio Brachydanio rerio Q1MTD3 400 45942 A369 D H A K R K A A D P A V R R P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VJQ4 427 48660 E396 V G T L S K S E W E A A T L Y
Honey Bee Apis mellifera XP_395738 367 42655 N336 Y Q H I K E Y N M K S S S I G
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_785441 457 51312 V422 E E E K T E E V A N G N G E E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LHQ7 370 42219 R339 L Y L S F V L R K R G E S D G
Baker's Yeast Sacchar. cerevisiae P32783 436 50322 V404 R S D G R Y G V E G D E K E A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 N.A. 85.7 N.A. 74.7 76 N.A. 55.2 62.6 59.4 52.7 N.A. 39 38.8 N.A. 46
Protein Similarity: 100 99.3 N.A. 90.1 N.A. 84 84 N.A. 63.7 72 71.8 67.8 N.A. 58.8 54.2 N.A. 61.5
P-Site Identity: 100 100 N.A. 13.3 N.A. 73.3 86.6 N.A. 73.3 0 0 6.6 N.A. 0 20 N.A. 6.6
P-Site Similarity: 100 100 N.A. 20 N.A. 86.6 93.3 N.A. 80 33.3 26.6 20 N.A. 26.6 33.3 N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. 28.7 29.4 N.A.
Protein Similarity: N.A. N.A. N.A. 43.2 47 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 29 8 36 29 8 8 8 0 22 15 0 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 43 0 8 0 0 0 0 0 15 0 8 0 0 8 0 % D
% Glu: 22 8 29 0 8 22 22 15 8 8 0 15 8 15 8 % E
% Phe: 0 0 0 0 8 8 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 8 0 8 0 0 8 0 0 22 15 8 8 0 15 % G
% His: 0 22 8 36 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 8 0 0 8 0 8 0 0 8 0 8 0 % I
% Lys: 0 0 0 22 15 15 22 8 15 43 15 0 22 8 0 % K
% Leu: 8 0 8 8 0 0 8 0 8 8 0 0 0 22 0 % L
% Met: 0 0 0 0 0 8 0 0 29 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 8 0 8 8 8 8 29 8 0 0 0 % N
% Pro: 8 0 8 0 0 0 0 0 0 8 0 0 0 0 22 % P
% Gln: 0 8 0 8 0 0 0 0 0 0 8 0 36 0 0 % Q
% Arg: 8 0 0 0 15 0 0 8 0 8 0 0 8 8 36 % R
% Ser: 0 8 0 8 8 0 8 8 0 0 8 43 15 0 0 % S
% Thr: 0 0 15 0 8 0 0 0 0 0 0 0 8 8 0 % T
% Val: 8 0 0 0 0 15 8 15 0 0 0 8 0 29 8 % V
% Trp: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % W
% Tyr: 8 50 0 0 0 8 8 36 0 0 0 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _