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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRPF4
All Species:
28.79
Human Site:
S426
Identified Species:
42.22
UniProt:
O43172
Number Species:
15
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43172
NP_004688.2
522
58449
S426
G
Y
H
I
A
T
G
S
G
D
N
T
C
K
V
Chimpanzee
Pan troglodytes
XP_520198
559
62217
S463
G
Y
H
I
A
T
G
S
G
D
N
T
C
K
V
Rhesus Macaque
Macaca mulatta
XP_001102859
521
58408
S425
G
Y
H
I
A
T
G
S
G
D
N
T
C
K
V
Dog
Lupus familis
XP_532038
521
58332
S425
G
Y
H
I
A
T
G
S
G
D
N
T
C
K
V
Cat
Felis silvestris
Mouse
Mus musculus
Q9DAW6
521
58352
S425
G
Y
H
I
A
T
G
S
G
D
N
T
C
K
V
Rat
Rattus norvegicus
Q5BK30
415
45841
T320
Y
T
G
K
L
I
A
T
A
S
A
D
G
T
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518220
390
43930
G295
Y
H
I
A
T
G
S
G
D
N
T
C
K
V
W
Chicken
Gallus gallus
Q5ZMA2
505
55116
T410
E
N
G
Y
Y
L
A
T
A
A
D
D
S
S
V
Frog
Xenopus laevis
Q5FWQ6
415
45899
T320
S
T
G
Q
L
V
A
T
A
S
A
D
G
T
A
Zebra Danio
Brachydanio rerio
Q1LV15
415
45916
T320
Y
T
G
Q
L
I
A
T
A
S
A
D
G
T
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q7KNS3
411
46441
G315
Q
G
P
F
L
A
S
G
S
R
D
K
T
I
R
Honey Bee
Apis mellifera
XP_393186
525
59172
S427
G
F
H
I
A
T
A
S
E
D
N
T
C
K
I
Nematode Worm
Caenorhab. elegans
Q10051
492
53189
T397
E
N
G
Y
Y
L
A
T
G
S
E
D
G
E
V
Sea Urchin
Strong. purpuratus
XP_795434
502
56264
S406
G
Y
Q
L
A
T
G
S
E
D
N
T
A
K
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O22212
554
61823
G442
G
Y
H
L
A
S
G
G
E
D
N
Q
C
R
I
Baker's Yeast
Sacchar. cerevisiae
P20053
465
52424
D370
Q
V
A
T
G
G
G
D
G
I
I
N
V
W
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.8
99
99.2
N.A.
98.8
25.4
N.A.
71.2
21
24.1
24.3
N.A.
22.2
58.2
22
62
Protein Similarity:
100
93.1
99.2
99.6
N.A.
99.4
40.6
N.A.
73.3
41.3
41.3
41.5
N.A.
39.6
72.9
40.6
77
P-Site Identity:
100
100
100
100
N.A.
100
0
N.A.
0
6.6
0
0
N.A.
0
73.3
13.3
66.6
P-Site Similarity:
100
100
100
100
N.A.
100
6.6
N.A.
13.3
20
6.6
6.6
N.A.
6.6
86.6
26.6
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
40
31.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
55.7
51.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
53.3
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
80
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
7
50
7
38
0
25
7
19
0
7
0
13
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
7
44
0
0
% C
% Asp:
0
0
0
0
0
0
0
7
7
50
13
32
0
0
7
% D
% Glu:
13
0
0
0
0
0
0
0
19
0
7
0
0
7
0
% E
% Phe:
0
7
0
7
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
50
7
32
0
7
13
50
19
44
0
0
0
25
0
0
% G
% His:
0
7
44
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
7
38
0
13
0
0
0
7
7
0
0
7
19
% I
% Lys:
0
0
0
7
0
0
0
0
0
0
0
7
7
44
0
% K
% Leu:
0
0
0
13
25
13
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
13
0
0
0
0
0
0
0
7
50
7
0
0
0
% N
% Pro:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
13
0
7
13
0
0
0
0
0
0
0
7
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
7
0
0
0
7
7
% R
% Ser:
7
0
0
0
0
7
13
44
7
25
0
0
7
7
7
% S
% Thr:
0
19
0
7
7
44
0
32
0
0
7
44
7
19
0
% T
% Val:
0
7
0
0
0
7
0
0
0
0
0
0
7
7
44
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
7
% W
% Tyr:
19
44
0
13
13
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _