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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PHGDH
All Species:
41.82
Human Site:
S127
Identified Species:
65.71
UniProt:
O43175
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43175
NP_006614.2
533
56651
S127
Q
I
P
Q
A
T
A
S
M
K
D
G
K
W
E
Chimpanzee
Pan troglodytes
A5A6P1
533
56644
S127
Q
I
P
Q
A
T
A
S
M
K
D
G
K
W
E
Rhesus Macaque
Macaca mulatta
XP_001114128
533
56466
S127
Q
I
P
Q
A
T
A
S
M
K
D
G
K
W
E
Dog
Lupus familis
XP_849835
533
56527
S127
H
I
P
Q
A
T
A
S
M
K
D
G
K
W
E
Cat
Felis silvestris
Mouse
Mus musculus
Q61753
533
56567
S127
Q
I
P
Q
A
T
A
S
M
K
D
G
K
W
D
Rat
Rattus norvegicus
O08651
533
56475
S127
Q
I
P
Q
A
T
A
S
M
K
D
G
K
W
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515318
533
55943
S127
Q
I
P
Q
A
S
A
S
M
K
D
G
K
W
D
Chicken
Gallus gallus
XP_422226
525
55022
S127
Q
I
P
Q
A
A
A
S
M
K
E
G
K
W
D
Frog
Xenopus laevis
NP_001091250
509
53841
S128
Q
I
P
Q
A
A
E
S
M
R
A
G
K
W
D
Zebra Danio
Brachydanio rerio
NP_955871
527
55379
S127
H
I
P
Q
A
V
I
S
M
K
D
G
K
W
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609496
332
35216
Honey Bee
Apis mellifera
XP_001121753
478
51893
I113
C
E
L
T
C
A
L
I
S
N
L
A
R
N
V
Nematode Worm
Caenorhab. elegans
NP_496868
322
34673
Sea Urchin
Strong. purpuratus
XP_001203904
493
51557
K109
M
G
S
E
L
Y
G
K
T
L
G
I
V
G
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04130
624
66436
S203
N
V
A
Q
A
D
A
S
I
K
A
G
K
W
E
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
98.8
92.5
N.A.
94.5
94.1
N.A.
82.5
67.5
56.2
60.7
N.A.
35
45
32.6
46.3
Protein Similarity:
100
99.6
99.2
96
N.A.
97
97.1
N.A.
90.2
80.1
71.6
75.9
N.A.
48.2
61.9
45.5
61.5
P-Site Identity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
86.6
80
66.6
73.3
N.A.
0
0
0
0
P-Site Similarity:
100
100
100
93.3
N.A.
100
100
N.A.
100
93.3
80
80
N.A.
0
6.6
0
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
33.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
60
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
73.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
0
74
20
60
0
0
0
14
7
0
0
0
% A
% Cys:
7
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
7
0
0
0
0
54
0
0
0
40
% D
% Glu:
0
7
0
7
0
0
7
0
0
0
7
0
0
0
34
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
7
0
0
0
0
7
0
0
0
7
74
0
7
0
% G
% His:
14
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
67
0
0
0
0
7
7
7
0
0
7
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
7
0
67
0
0
74
0
0
% K
% Leu:
0
0
7
0
7
0
7
0
0
7
7
0
0
0
7
% L
% Met:
7
0
0
0
0
0
0
0
67
0
0
0
0
0
0
% M
% Asn:
7
0
0
0
0
0
0
0
0
7
0
0
0
7
0
% N
% Pro:
0
0
67
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
54
0
0
74
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
7
0
0
7
0
0
% R
% Ser:
0
0
7
0
0
7
0
74
7
0
0
0
0
0
0
% S
% Thr:
0
0
0
7
0
40
0
0
7
0
0
0
0
0
0
% T
% Val:
0
7
0
0
0
7
0
0
0
0
0
0
7
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
74
0
% W
% Tyr:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _