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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PHGDH
All Species:
32.42
Human Site:
S501
Identified Species:
50.95
UniProt:
O43175
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43175
NP_006614.2
533
56651
S501
S
Y
Q
T
S
L
V
S
D
G
E
T
W
H
V
Chimpanzee
Pan troglodytes
A5A6P1
533
56644
S501
S
Y
Q
T
S
L
V
S
D
G
E
T
W
H
V
Rhesus Macaque
Macaca mulatta
XP_001114128
533
56466
S501
S
Y
Q
T
S
L
V
S
D
G
E
T
W
H
V
Dog
Lupus familis
XP_849835
533
56527
S501
S
Y
Q
T
S
V
V
S
D
G
E
T
W
H
V
Cat
Felis silvestris
Mouse
Mus musculus
Q61753
533
56567
S501
S
Y
Q
T
S
M
V
S
D
G
E
P
W
H
V
Rat
Rattus norvegicus
O08651
533
56475
S501
S
Y
Q
T
S
K
V
S
D
G
D
T
W
H
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515318
533
55943
S501
S
Y
Q
T
S
D
G
S
D
G
A
A
W
H
I
Chicken
Gallus gallus
XP_422226
525
55022
V493
S
Y
H
S
S
S
A
V
V
G
E
Q
W
S
I
Frog
Xenopus laevis
NP_001091250
509
53841
L477
L
S
E
A
G
S
Q
L
E
M
L
H
V
S
N
Zebra Danio
Brachydanio rerio
NP_955871
527
55379
S495
S
F
S
A
S
S
S
S
G
G
E
K
W
Y
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609496
332
35216
E301
A
Q
V
R
V
A
V
E
V
A
E
Q
F
I
A
Honey Bee
Apis mellifera
XP_001121753
478
51893
S445
A
Q
I
V
N
V
F
S
L
K
N
I
N
I
C
Nematode Worm
Caenorhab. elegans
NP_496868
322
34673
A291
L
G
A
S
T
I
D
A
Q
L
R
V
A
S
E
Sea Urchin
Strong. purpuratus
XP_001203904
493
51557
T461
A
F
S
S
S
A
Q
T
N
G
E
S
W
S
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04130
624
66436
V587
F
M
S
V
G
R
T
V
L
R
K
Q
A
I
M
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
98.8
92.5
N.A.
94.5
94.1
N.A.
82.5
67.5
56.2
60.7
N.A.
35
45
32.6
46.3
Protein Similarity:
100
99.6
99.2
96
N.A.
97
97.1
N.A.
90.2
80.1
71.6
75.9
N.A.
48.2
61.9
45.5
61.5
P-Site Identity:
100
100
100
93.3
N.A.
86.6
86.6
N.A.
66.6
40
0
40
N.A.
13.3
6.6
0
33.3
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
73.3
53.3
13.3
53.3
N.A.
26.6
26.6
26.6
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
33.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
20
0
7
14
0
14
7
7
0
7
7
7
14
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
14
% C
% Asp:
0
0
0
0
0
7
7
0
47
0
7
0
0
0
0
% D
% Glu:
0
0
7
0
0
0
0
7
7
0
60
0
0
0
7
% E
% Phe:
7
14
0
0
0
0
7
0
0
0
0
0
7
0
0
% F
% Gly:
0
7
0
0
14
0
7
0
7
67
0
0
0
0
0
% G
% His:
0
0
7
0
0
0
0
0
0
0
0
7
0
47
0
% H
% Ile:
0
0
7
0
0
7
0
0
0
0
0
7
0
20
14
% I
% Lys:
0
0
0
0
0
7
0
0
0
7
7
7
0
0
0
% K
% Leu:
14
0
0
0
0
20
0
7
14
7
7
0
0
0
0
% L
% Met:
0
7
0
0
0
7
0
0
0
7
0
0
0
0
7
% M
% Asn:
0
0
0
0
7
0
0
0
7
0
7
0
7
0
7
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% P
% Gln:
0
14
47
0
0
0
14
0
7
0
0
20
0
0
0
% Q
% Arg:
0
0
0
7
0
7
0
0
0
7
7
0
0
0
0
% R
% Ser:
60
7
20
20
67
20
7
60
0
0
0
7
0
27
0
% S
% Thr:
0
0
0
47
7
0
7
7
0
0
0
34
0
0
0
% T
% Val:
0
0
7
14
7
14
47
14
14
0
0
7
7
0
47
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
67
0
0
% W
% Tyr:
0
54
0
0
0
0
0
0
0
0
0
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _