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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PHGDH All Species: 24.55
Human Site: S517 Identified Species: 38.57
UniProt: O43175 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.21
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O43175 NP_006614.2 533 56651 S517 G I S S L L P S L E A W K Q H
Chimpanzee Pan troglodytes A5A6P1 533 56644 S517 G I P S L L P S L E A W K Q H
Rhesus Macaque Macaca mulatta XP_001114128 533 56466 S517 G I S S L L P S L E A W K P H
Dog Lupus familis XP_849835 533 56527 S517 G I S S L L P S L E A W K Q H
Cat Felis silvestris
Mouse Mus musculus Q61753 533 56567 S517 G L S S L L P S L E T W K Q H
Rat Rattus norvegicus O08651 533 56475 S517 G L S S L L P S L D A W K Q H
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515318 533 55943 N517 G I S S T L P N L D T W K Q H
Chicken Gallus gallus XP_422226 525 55022 D509 G L S A P L S D L A G L K P C
Frog Xenopus laevis NP_001091250 509 53841 S493 H S V A G I S S P V S D L S L
Zebra Danio Brachydanio rerio NP_955871 527 55379 D511 G I S S L L G D I G A L K S L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_609496 332 35216 T317 N G T S P K Y T S Y A G V I N
Honey Bee Apis mellifera XP_001121753 478 51893 M461 L N T N G N W M I I Q T D R E
Nematode Worm Caenorhab. elegans NP_496868 322 34673 N307 A D N I V Q Y N K G T M L G V
Sea Urchin Strong. purpuratus XP_001203904 493 51557 G477 K L A T P Q P G V E A L A G A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O04130 624 66436 D603 I G V D E E P D N K T L E R I
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 98.8 92.5 N.A. 94.5 94.1 N.A. 82.5 67.5 56.2 60.7 N.A. 35 45 32.6 46.3
Protein Similarity: 100 99.6 99.2 96 N.A. 97 97.1 N.A. 90.2 80.1 71.6 75.9 N.A. 48.2 61.9 45.5 61.5
P-Site Identity: 100 93.3 93.3 100 N.A. 86.6 86.6 N.A. 73.3 33.3 6.6 53.3 N.A. 13.3 0 0 20
P-Site Similarity: 100 93.3 93.3 100 N.A. 93.3 100 N.A. 86.6 46.6 26.6 60 N.A. 33.3 26.6 20 46.6
Percent
Protein Identity: N.A. N.A. N.A. 33.1 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 48.5 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 7 14 0 0 0 0 0 7 54 0 7 0 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % C
% Asp: 0 7 0 7 0 0 0 20 0 14 0 7 7 0 0 % D
% Glu: 0 0 0 0 7 7 0 0 0 40 0 0 7 0 7 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 60 14 0 0 14 0 7 7 0 14 7 7 0 14 0 % G
% His: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 47 % H
% Ile: 7 40 0 7 0 7 0 0 14 7 0 0 0 7 7 % I
% Lys: 7 0 0 0 0 7 0 0 7 7 0 0 60 0 0 % K
% Leu: 7 27 0 0 47 60 0 0 54 0 0 27 14 0 14 % L
% Met: 0 0 0 0 0 0 0 7 0 0 0 7 0 0 0 % M
% Asn: 7 7 7 7 0 7 0 14 7 0 0 0 0 0 7 % N
% Pro: 0 0 7 0 20 0 60 0 7 0 0 0 0 14 0 % P
% Gln: 0 0 0 0 0 14 0 0 0 0 7 0 0 40 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 14 0 % R
% Ser: 0 7 54 60 0 0 14 47 7 0 7 0 0 14 0 % S
% Thr: 0 0 14 7 7 0 0 7 0 0 27 7 0 0 0 % T
% Val: 0 0 14 0 7 0 0 0 7 7 0 0 7 0 7 % V
% Trp: 0 0 0 0 0 0 7 0 0 0 0 47 0 0 0 % W
% Tyr: 0 0 0 0 0 0 14 0 0 7 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _