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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PHGDH
All Species:
41.52
Human Site:
T221
Identified Species:
65.24
UniProt:
O43175
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43175
NP_006614.2
533
56651
T221
T
G
L
L
N
D
N
T
F
A
Q
C
K
K
G
Chimpanzee
Pan troglodytes
A5A6P1
533
56644
T221
T
G
L
L
N
D
N
T
F
A
Q
C
K
K
G
Rhesus Macaque
Macaca mulatta
XP_001114128
533
56466
T221
T
G
L
L
N
D
N
T
F
A
Q
C
K
K
G
Dog
Lupus familis
XP_849835
533
56527
T221
T
G
L
L
N
D
S
T
F
A
Q
C
K
K
G
Cat
Felis silvestris
Mouse
Mus musculus
Q61753
533
56567
T221
T
G
L
L
N
D
S
T
F
A
Q
C
K
K
G
Rat
Rattus norvegicus
O08651
533
56475
T221
T
G
L
L
N
D
S
T
F
A
Q
C
K
K
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515318
533
55943
T221
T
G
L
L
N
D
A
T
F
A
K
C
K
K
G
Chicken
Gallus gallus
XP_422226
525
55022
T221
T
G
L
L
N
D
S
T
F
A
K
C
R
R
G
Frog
Xenopus laevis
NP_001091250
509
53841
A222
T
G
L
I
N
D
A
A
F
S
K
C
K
Q
G
Zebra Danio
Brachydanio rerio
NP_955871
527
55379
S221
T
G
L
L
N
D
A
S
F
A
K
C
K
K
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609496
332
35216
S67
A
E
V
L
A
A
G
S
G
S
L
K
V
V
G
Honey Bee
Apis mellifera
XP_001121753
478
51893
T203
W
P
M
A
D
Y
I
T
V
H
T
P
L
I
P
Nematode Worm
Caenorhab. elegans
NP_496868
322
34673
T59
V
R
S
A
T
K
I
T
A
E
L
L
A
A
S
Sea Urchin
Strong. purpuratus
XP_001203904
493
51557
R199
V
K
V
V
N
V
A
R
G
G
I
I
D
E
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04130
624
66436
T297
K
K
V
F
N
D
E
T
F
S
K
M
K
K
G
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
98.8
92.5
N.A.
94.5
94.1
N.A.
82.5
67.5
56.2
60.7
N.A.
35
45
32.6
46.3
Protein Similarity:
100
99.6
99.2
96
N.A.
97
97.1
N.A.
90.2
80.1
71.6
75.9
N.A.
48.2
61.9
45.5
61.5
P-Site Identity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
86.6
73.3
60
80
N.A.
13.3
6.6
6.6
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
93.3
100
86.6
93.3
N.A.
33.3
20
6.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
33.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
46.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
66.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
14
7
7
27
7
7
60
0
0
7
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
67
0
0
0
% C
% Asp:
0
0
0
0
7
74
0
0
0
0
0
0
7
0
0
% D
% Glu:
0
7
0
0
0
0
7
0
0
7
0
0
0
7
7
% E
% Phe:
0
0
0
7
0
0
0
0
74
0
0
0
0
0
0
% F
% Gly:
0
67
0
0
0
0
7
0
14
7
0
0
0
0
80
% G
% His:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% H
% Ile:
0
0
0
7
0
0
14
0
0
0
7
7
0
7
0
% I
% Lys:
7
14
0
0
0
7
0
0
0
0
34
7
67
60
0
% K
% Leu:
0
0
67
67
0
0
0
0
0
0
14
7
7
0
0
% L
% Met:
0
0
7
0
0
0
0
0
0
0
0
7
0
0
0
% M
% Asn:
0
0
0
0
80
0
20
0
0
0
0
0
0
0
0
% N
% Pro:
0
7
0
0
0
0
0
0
0
0
0
7
0
0
7
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
40
0
0
7
0
% Q
% Arg:
0
7
0
0
0
0
0
7
0
0
0
0
7
7
0
% R
% Ser:
0
0
7
0
0
0
27
14
0
20
0
0
0
0
7
% S
% Thr:
67
0
0
0
7
0
0
74
0
0
7
0
0
0
0
% T
% Val:
14
0
20
7
0
7
0
0
7
0
0
0
7
7
0
% V
% Trp:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _