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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ADAM12
All Species:
8.18
Human Site:
S44
Identified Species:
18
UniProt:
O43184
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43184
NP_003465.3
909
99542
S44
G
R
A
D
E
V
V
S
A
S
V
G
S
G
D
Chimpanzee
Pan troglodytes
XP_508106
914
100282
N43
A
G
G
V
S
L
W
N
Q
G
R
A
D
E
V
Rhesus Macaque
Macaca mulatta
XP_001087980
909
99411
S44
G
G
A
D
E
V
V
S
V
S
V
W
S
G
D
Dog
Lupus familis
XP_546274
909
99674
T43
R
I
I
P
Q
W
K
T
A
E
S
P
T
K
E
Cat
Felis silvestris
Mouse
Mus musculus
Q61824
903
98582
D36
A
R
G
M
S
L
W
D
Q
R
G
A
Y
E
V
Rat
Rattus norvegicus
Q9QYV0
816
88034
S42
A
S
P
E
R
T
Q
S
R
S
L
E
N
Q
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507222
856
93750
S35
G
Y
T
E
T
H
Y
S
E
S
G
A
P
Q
T
Chicken
Gallus gallus
NP_001136322
922
101009
M50
L
E
S
L
R
Q
Q
M
L
K
D
Q
S
K
D
Frog
Xenopus laevis
O42596
935
104143
G46
K
K
E
N
S
V
L
G
M
E
D
T
V
P
L
Zebra Danio
Brachydanio rerio
XP_001921148
773
83366
S30
S
I
I
A
Y
K
P
S
P
Y
Y
L
G
F
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_999635
1023
111059
N46
E
Q
L
G
K
L
L
N
Y
D
I
V
T
P
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.3
94.8
43.7
N.A.
80.3
35.5
N.A.
43.3
71.5
28.3
56.7
N.A.
N.A.
N.A.
N.A.
35.8
Protein Similarity:
100
95.9
97.1
59.4
N.A.
88.1
50.3
N.A.
58
82.4
44.4
65.2
N.A.
N.A.
N.A.
N.A.
51.2
P-Site Identity:
100
0
80
6.6
N.A.
6.6
13.3
N.A.
20
13.3
6.6
6.6
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
13.3
80
33.3
N.A.
13.3
33.3
N.A.
26.6
20
26.6
6.6
N.A.
N.A.
N.A.
N.A.
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
28
0
19
10
0
0
0
0
19
0
0
28
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
19
0
0
0
10
0
10
19
0
10
0
28
% D
% Glu:
10
10
10
19
19
0
0
0
10
19
0
10
0
19
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% F
% Gly:
28
19
19
10
0
0
0
10
0
10
19
10
10
19
0
% G
% His:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
19
19
0
0
0
0
0
0
0
10
0
0
0
10
% I
% Lys:
10
10
0
0
10
10
10
0
0
10
0
0
0
19
0
% K
% Leu:
10
0
10
10
0
28
19
0
10
0
10
10
0
0
10
% L
% Met:
0
0
0
10
0
0
0
10
10
0
0
0
0
0
0
% M
% Asn:
0
0
0
10
0
0
0
19
0
0
0
0
10
0
0
% N
% Pro:
0
0
10
10
0
0
10
0
10
0
0
10
10
19
0
% P
% Gln:
0
10
0
0
10
10
19
0
19
0
0
10
0
19
0
% Q
% Arg:
10
19
0
0
19
0
0
0
10
10
10
0
0
0
0
% R
% Ser:
10
10
10
0
28
0
0
46
0
37
10
0
28
0
0
% S
% Thr:
0
0
10
0
10
10
0
10
0
0
0
10
19
0
10
% T
% Val:
0
0
0
10
0
28
19
0
10
0
19
10
10
0
28
% V
% Trp:
0
0
0
0
0
10
19
0
0
0
0
10
0
0
0
% W
% Tyr:
0
10
0
0
10
0
10
0
10
10
10
0
10
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _