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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CRX All Species: 16.67
Human Site: S245 Identified Species: 36.67
UniProt: O43186 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O43186 NP_000545.1 299 32261 S245 S G P S V G P S L A Q S P T S
Chimpanzee Pan troglodytes XP_524319 298 32142 S244 S G P S V G P S L A Q S P T S
Rhesus Macaque Macaca mulatta NP_001171116 297 32414 P243 T S H L N Q S P A S L S T Q G
Dog Lupus familis XP_547830 289 31604 P235 T S H L N Q S P A S L S T Q G
Cat Felis silvestris
Mouse Mus musculus O54751 299 32356 S245 S G P S V G P S L A Q S P T S
Rat Rattus norvegicus Q63410 355 37584 H259 L A P M H S H H H P H Q L S P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis Q9PVM0 290 31534 S236 M G S H L S Q S P A S L S A Q
Zebra Danio Brachydanio rerio Q91981 289 31576 S234 V T S H L N Q S P A S L P T Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P22810 542 55168 S274 S S G G G G G S Q A G G H L S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q93356 278 30883 S225 S S I T A T S S L P T T S S S
Sea Urchin Strong. purpuratus Q26417 371 41197 S317 H M P Q F P G S I N H Q M A A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 55.1 54.8 N.A. 96.6 40.2 N.A. N.A. N.A. 58.1 54.1 N.A. 26.3 N.A. 31.4 34.5
Protein Similarity: 100 99.3 67.2 67.5 N.A. 97.3 54.3 N.A. N.A. N.A. 72.5 66.5 N.A. 34.8 N.A. 46.4 46.9
P-Site Identity: 100 100 6.6 6.6 N.A. 100 6.6 N.A. N.A. N.A. 20 26.6 N.A. 33.3 N.A. 26.6 13.3
P-Site Similarity: 100 100 20 20 N.A. 100 13.3 N.A. N.A. N.A. 26.6 33.3 N.A. 33.3 N.A. 46.6 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 10 0 0 10 0 0 0 19 55 0 0 0 19 10 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 37 10 10 10 37 19 0 0 0 10 10 0 0 19 % G
% His: 10 0 19 19 10 0 10 10 10 0 19 0 10 0 0 % H
% Ile: 0 0 10 0 0 0 0 0 10 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 10 0 0 19 19 0 0 0 37 0 19 19 10 10 0 % L
% Met: 10 10 0 10 0 0 0 0 0 0 0 0 10 0 0 % M
% Asn: 0 0 0 0 19 10 0 0 0 10 0 0 0 0 0 % N
% Pro: 0 0 46 0 0 10 28 19 19 19 0 0 37 0 10 % P
% Gln: 0 0 0 10 0 19 19 0 10 0 28 19 0 19 19 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 46 37 19 28 0 19 28 73 0 19 19 46 19 19 46 % S
% Thr: 19 10 0 10 0 10 0 0 0 0 10 10 19 37 0 % T
% Val: 10 0 0 0 28 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _