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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH5
All Species:
6.06
Human Site:
S22
Identified Species:
13.33
UniProt:
O43196
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43196
NP_002432.1
834
92875
S22
P
R
P
G
A
A
S
S
G
F
P
S
P
A
P
Chimpanzee
Pan troglodytes
XP_001158290
834
92790
S22
P
G
P
G
A
A
S
S
G
F
P
S
P
A
P
Rhesus Macaque
Macaca mulatta
XP_001105745
834
92745
G22
P
G
P
G
A
A
S
G
F
S
S
P
A
P
V
Dog
Lupus familis
XP_532080
826
92316
A22
P
R
P
Q
A
A
L
A
T
C
S
S
P
A
P
Cat
Felis silvestris
Mouse
Mus musculus
Q9QUM7
833
92583
A23
P
R
S
G
I
P
S
A
S
F
P
S
P
Q
P
Rat
Rattus norvegicus
Q6MG62
831
92433
S25
V
P
S
A
S
F
S
S
P
Q
P
A
M
A
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516940
319
34130
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_698552
793
89282
N22
S
R
S
P
S
V
M
N
E
D
E
D
D
G
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002317341
531
60118
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_188683
807
91104
G25
I
Q
H
G
R
R
V
G
V
S
Y
Y
D
C
S
Baker's Yeast
Sacchar. cerevisiae
Q12175
901
102190
G67
V
M
C
I
D
F
S
G
G
K
L
G
C
S
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
97.8
88.7
N.A.
88.8
88
N.A.
29
N.A.
N.A.
52.7
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.5
98.6
93.7
N.A.
93.5
93.1
N.A.
32.3
N.A.
N.A.
70.1
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
93.3
40
60
N.A.
60
26.6
N.A.
0
N.A.
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
93.3
40
66.6
N.A.
66.6
40
N.A.
0
N.A.
N.A.
20
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
21.9
N.A.
N.A.
30.4
24.5
N.A.
Protein Similarity:
36.8
N.A.
N.A.
50.8
43.9
N.A.
P-Site Identity:
0
N.A.
N.A.
6.6
13.3
N.A.
P-Site Similarity:
0
N.A.
N.A.
13.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
10
37
37
0
19
0
0
0
10
10
37
10
% A
% Cys:
0
0
10
0
0
0
0
0
0
10
0
0
10
10
0
% C
% Asp:
0
0
0
0
10
0
0
0
0
10
0
10
19
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
10
0
10
0
0
0
0
% E
% Phe:
0
0
0
0
0
19
0
0
10
28
0
0
0
0
0
% F
% Gly:
0
19
0
46
0
0
0
28
28
0
0
10
0
10
0
% G
% His:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
10
0
0
10
10
0
0
0
0
0
0
0
0
0
10
% I
% Lys:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
10
0
0
0
10
0
0
0
0
% L
% Met:
0
10
0
0
0
0
10
0
0
0
0
0
10
0
0
% M
% Asn:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% N
% Pro:
46
10
37
10
0
10
0
0
10
0
37
10
37
10
37
% P
% Gln:
0
10
0
10
0
0
0
0
0
10
0
0
0
10
0
% Q
% Arg:
0
37
0
0
10
10
0
0
0
0
0
0
0
0
10
% R
% Ser:
10
0
28
0
19
0
55
28
10
19
19
37
0
10
10
% S
% Thr:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% T
% Val:
19
0
0
0
0
10
10
0
10
0
0
0
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
10
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _