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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH5
All Species:
26.67
Human Site:
S356
Identified Species:
58.67
UniProt:
O43196
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43196
NP_002432.1
834
92875
S356
A
C
R
S
L
P
Q
S
I
Q
L
F
R
D
I
Chimpanzee
Pan troglodytes
XP_001158290
834
92790
S356
A
C
R
S
L
P
Q
S
I
Q
L
F
R
D
I
Rhesus Macaque
Macaca mulatta
XP_001105745
834
92745
S355
A
C
R
S
L
P
Q
S
I
Q
L
F
R
D
I
Dog
Lupus familis
XP_532080
826
92316
S348
A
C
R
S
L
P
Q
S
I
Q
L
F
Q
D
I
Cat
Felis silvestris
Mouse
Mus musculus
Q9QUM7
833
92583
S355
A
C
R
S
L
P
Q
S
I
Q
L
F
Q
D
I
Rat
Rattus norvegicus
Q6MG62
831
92433
S353
A
C
R
S
L
P
Q
S
I
Q
L
F
R
D
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516940
319
34130
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_698552
793
89282
S316
T
I
R
S
L
P
Q
S
I
Q
L
F
R
E
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002317341
531
60118
G95
D
K
H
P
S
H
M
G
I
G
R
A
K
E
G
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_188683
807
91104
G336
L
D
I
I
E
K
A
G
L
C
I
S
T
E
L
Baker's Yeast
Sacchar. cerevisiae
Q12175
901
102190
G381
L
V
S
S
L
K
L
G
S
D
E
A
N
I
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
97.8
88.7
N.A.
88.8
88
N.A.
29
N.A.
N.A.
52.7
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.5
98.6
93.7
N.A.
93.5
93.1
N.A.
32.3
N.A.
N.A.
70.1
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
93.3
100
N.A.
0
N.A.
N.A.
80
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
0
N.A.
N.A.
86.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
21.9
N.A.
N.A.
30.4
24.5
N.A.
Protein Similarity:
36.8
N.A.
N.A.
50.8
43.9
N.A.
P-Site Identity:
6.6
N.A.
N.A.
0
13.3
N.A.
P-Site Similarity:
20
N.A.
N.A.
26.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
55
0
0
0
0
0
10
0
0
0
0
19
0
0
0
% A
% Cys:
0
55
0
0
0
0
0
0
0
10
0
0
0
0
0
% C
% Asp:
10
10
0
0
0
0
0
0
0
10
0
0
0
55
0
% D
% Glu:
0
0
0
0
10
0
0
0
0
0
10
0
0
28
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
64
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
28
0
10
0
0
0
0
10
% G
% His:
0
0
10
0
0
10
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
10
10
10
0
0
0
0
73
0
10
0
0
10
64
% I
% Lys:
0
10
0
0
0
19
0
0
0
0
0
0
10
0
0
% K
% Leu:
19
0
0
0
73
0
10
0
10
0
64
0
0
0
19
% L
% Met:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% N
% Pro:
0
0
0
10
0
64
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
64
0
0
64
0
0
19
0
0
% Q
% Arg:
0
0
64
0
0
0
0
0
0
0
10
0
46
0
0
% R
% Ser:
0
0
10
73
10
0
0
64
10
0
0
10
0
0
0
% S
% Thr:
10
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% T
% Val:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _