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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH5
All Species:
22.12
Human Site:
Y242
Identified Species:
48.67
UniProt:
O43196
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43196
NP_002432.1
834
92875
Y242
S
E
S
H
P
S
V
Y
K
V
A
S
G
L
K
Chimpanzee
Pan troglodytes
XP_001158290
834
92790
Y242
S
E
S
H
P
S
V
Y
K
V
A
S
G
L
K
Rhesus Macaque
Macaca mulatta
XP_001105745
834
92745
Y241
S
E
S
H
P
S
A
Y
K
V
A
S
G
L
K
Dog
Lupus familis
XP_532080
826
92316
Y234
S
E
P
H
P
S
V
Y
K
V
A
S
G
L
K
Cat
Felis silvestris
Mouse
Mus musculus
Q9QUM7
833
92583
Y241
S
E
S
H
P
S
V
Y
K
V
A
S
G
L
K
Rat
Rattus norvegicus
Q6MG62
831
92433
Y239
S
E
S
H
P
S
V
Y
K
V
A
S
G
L
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516940
319
34130
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_698552
793
89282
L223
S
E
L
H
P
S
V
L
K
L
Q
S
G
V
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002317341
531
60118
G13
D
V
Q
V
R
A
S
G
G
L
L
A
I
L
E
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_188683
807
91104
L241
S
W
F
M
R
P
I
L
D
L
E
V
L
D
R
Baker's Yeast
Sacchar. cerevisiae
Q12175
901
102190
K270
A
H
K
L
G
H
D
K
M
M
R
N
G
F
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
97.8
88.7
N.A.
88.8
88
N.A.
29
N.A.
N.A.
52.7
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.5
98.6
93.7
N.A.
93.5
93.1
N.A.
32.3
N.A.
N.A.
70.1
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
93.3
93.3
N.A.
100
100
N.A.
0
N.A.
N.A.
66.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
93.3
93.3
N.A.
100
100
N.A.
0
N.A.
N.A.
80
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
21.9
N.A.
N.A.
30.4
24.5
N.A.
Protein Similarity:
36.8
N.A.
N.A.
50.8
43.9
N.A.
P-Site Identity:
6.6
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
33.3
N.A.
N.A.
26.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
0
0
10
10
0
0
0
55
10
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
0
0
0
0
10
0
10
0
0
0
0
10
0
% D
% Glu:
0
64
0
0
0
0
0
0
0
0
10
0
0
0
10
% E
% Phe:
0
0
10
0
0
0
0
0
0
0
0
0
0
10
10
% F
% Gly:
0
0
0
0
10
0
0
10
10
0
0
0
73
0
0
% G
% His:
0
10
0
64
0
10
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
10
0
0
0
0
0
10
0
0
% I
% Lys:
0
0
10
0
0
0
0
10
64
0
0
0
0
0
64
% K
% Leu:
0
0
10
10
0
0
0
19
0
28
10
0
10
64
0
% L
% Met:
0
0
0
10
0
0
0
0
10
10
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% N
% Pro:
0
0
10
0
64
10
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
10
0
0
0
0
0
0
0
10
0
0
0
0
% Q
% Arg:
0
0
0
0
19
0
0
0
0
0
10
0
0
0
10
% R
% Ser:
73
0
46
0
0
64
10
0
0
0
0
64
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
10
0
10
0
0
55
0
0
55
0
10
0
10
0
% V
% Trp:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
55
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _