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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MSH5 All Species: 24.24
Human Site: Y726 Identified Species: 53.33
UniProt: O43196 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O43196 NP_002432.1 834 92875 Y726 P Q G P L V Q Y L T M E T C E
Chimpanzee Pan troglodytes XP_001158290 834 92790 Y726 P Q G P L V Q Y L T M E T C E
Rhesus Macaque Macaca mulatta XP_001105745 834 92745 Y726 P Q G P L V Q Y L T M E T C E
Dog Lupus familis XP_532080 826 92316 Y718 P Q G P L V Q Y L T M E T C E
Cat Felis silvestris
Mouse Mus musculus Q9QUM7 833 92583 Y725 P Q G P L V Q Y L T M E T C E
Rat Rattus norvegicus Q6MG62 831 92433 Y723 P Q G P L V Q Y L T M E T C E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516940 319 34130 Q228 E E L V F F Y Q V R E G V A G
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_698552 793 89282 L685 P D S S L L A L L T L E T A I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002317341 531 60118 F440 K Q V A L I V F L S H I G S F
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_188683 807 91104 L707 K F Y T M S V L R P D T E S A
Baker's Yeast Sacchar. cerevisiae Q12175 901 102190 T793 Q K Y N L L E T A H V G E D H
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 97.8 88.7 N.A. 88.8 88 N.A. 29 N.A. N.A. 52.7 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 99.5 98.6 93.7 N.A. 93.5 93.1 N.A. 32.3 N.A. N.A. 70.1 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 0 N.A. N.A. 40 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 13.3 N.A. N.A. 53.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: 21.9 N.A. N.A. 30.4 24.5 N.A.
Protein Similarity: 36.8 N.A. N.A. 50.8 43.9 N.A.
P-Site Identity: 20 N.A. N.A. 0 6.6 N.A.
P-Site Similarity: 40 N.A. N.A. 6.6 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 10 0 0 10 0 10 0 0 0 0 19 10 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 55 0 % C
% Asp: 0 10 0 0 0 0 0 0 0 0 10 0 0 10 0 % D
% Glu: 10 10 0 0 0 0 10 0 0 0 10 64 19 0 55 % E
% Phe: 0 10 0 0 10 10 0 10 0 0 0 0 0 0 10 % F
% Gly: 0 0 55 0 0 0 0 0 0 0 0 19 10 0 10 % G
% His: 0 0 0 0 0 0 0 0 0 10 10 0 0 0 10 % H
% Ile: 0 0 0 0 0 10 0 0 0 0 0 10 0 0 10 % I
% Lys: 19 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 10 0 82 19 0 19 73 0 10 0 0 0 0 % L
% Met: 0 0 0 0 10 0 0 0 0 0 55 0 0 0 0 % M
% Asn: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 64 0 0 55 0 0 0 0 0 10 0 0 0 0 0 % P
% Gln: 10 64 0 0 0 0 55 10 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 10 10 0 0 0 0 0 % R
% Ser: 0 0 10 10 0 10 0 0 0 10 0 0 0 19 0 % S
% Thr: 0 0 0 10 0 0 0 10 0 64 0 10 64 0 0 % T
% Val: 0 0 10 10 0 55 19 0 10 0 10 0 10 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 19 0 0 0 10 55 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _