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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIAH2
All Species:
21.82
Human Site:
S180
Identified Species:
40
UniProt:
O43255
Number Species:
12
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43255
NP_005058.3
324
34615
S180
A
S
C
K
W
Q
G
S
L
E
A
V
M
S
H
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_863586
282
31108
D142
C
K
W
Q
G
S
L
D
A
V
M
P
H
L
M
Cat
Felis silvestris
Mouse
Mus musculus
Q06986
325
34739
S181
A
S
C
K
W
Q
G
S
L
E
A
V
M
S
H
Rat
Rattus norvegicus
Q8R4T2
325
34681
S181
A
S
C
K
W
Q
G
S
L
E
A
V
M
S
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507643
433
47638
S291
A
S
C
K
W
Q
G
S
L
D
A
V
M
P
H
Chicken
Gallus gallus
XP_426719
319
34023
S175
A
T
C
K
W
Q
G
S
L
E
A
V
M
S
H
Frog
Xenopus laevis
Q9I8X5
313
34081
N172
K
W
Q
G
S
L
E
N
V
M
Q
H
L
T
H
Zebra Danio
Brachydanio rerio
Q7SYL3
331
34475
S189
A
S
C
K
W
Q
G
S
L
E
E
V
M
P
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P21461
314
33689
P172
A
S
C
K
W
Q
G
P
L
D
L
V
M
Q
H
Honey Bee
Apis mellifera
XP_394284
279
30558
E139
C
K
W
Q
G
S
L
E
Q
V
M
P
H
L
V
Nematode Worm
Caenorhab. elegans
Q965X6
339
37641
G189
A
S
C
K
W
Q
G
G
L
S
D
V
M
E
H
Sea Urchin
Strong. purpuratus
XP_797311
281
31248
D141
C
K
W
Q
G
S
L
D
Q
V
M
P
H
L
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9STN8
327
36556
V178
H
L
R
D
D
H
K
V
D
M
H
A
G
S
T
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
70.6
N.A.
97.8
98.1
N.A.
56.5
91
85.8
76.1
N.A.
66.3
67.9
54.8
66.9
Protein Similarity:
100
N.A.
N.A.
78.4
N.A.
97.8
98.1
N.A.
63.9
93.5
88.2
82.4
N.A.
76.8
76.8
66.9
76.2
P-Site Identity:
100
N.A.
N.A.
0
N.A.
100
100
N.A.
86.6
93.3
6.6
86.6
N.A.
73.3
0
73.3
0
P-Site Similarity:
100
N.A.
N.A.
6.6
N.A.
100
100
N.A.
93.3
100
33.3
86.6
N.A.
80
6.6
73.3
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
30.2
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
47.7
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
62
0
0
0
0
0
0
0
8
0
39
8
0
0
0
% A
% Cys:
24
0
62
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
8
0
0
16
8
16
8
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
8
8
0
39
8
0
0
8
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
8
24
0
62
8
0
0
0
0
8
0
0
% G
% His:
8
0
0
0
0
8
0
0
0
0
8
8
24
0
70
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
8
24
0
62
0
0
8
0
0
0
0
0
0
0
0
% K
% Leu:
0
8
0
0
0
8
24
0
62
0
8
0
8
24
0
% L
% Met:
0
0
0
0
0
0
0
0
0
16
24
0
62
0
8
% M
% Asn:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
8
0
0
0
24
0
16
0
% P
% Gln:
0
0
8
24
0
62
0
0
16
0
8
0
0
8
0
% Q
% Arg:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
54
0
0
8
24
0
47
0
8
0
0
0
39
0
% S
% Thr:
0
8
0
0
0
0
0
0
0
0
0
0
0
8
16
% T
% Val:
0
0
0
0
0
0
0
8
8
24
0
62
0
0
8
% V
% Trp:
0
8
24
0
62
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _