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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIAH2
All Species:
11.52
Human Site:
S68
Identified Species:
21.11
UniProt:
O43255
Number Species:
12
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43255
NP_005058.3
324
34615
S68
G
G
G
A
G
P
V
S
P
Q
H
H
E
L
T
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_863586
282
31108
L38
S
N
N
D
L
A
S
L
F
E
C
P
V
C
F
Cat
Felis silvestris
Mouse
Mus musculus
Q06986
325
34739
S69
G
G
G
A
D
P
V
S
P
Q
H
H
E
L
T
Rat
Rattus norvegicus
Q8R4T2
325
34681
S69
G
G
G
A
G
P
V
S
P
Q
H
H
E
L
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507643
433
47638
T180
V
P
A
L
T
G
T
T
A
S
N
N
D
L
A
Chicken
Gallus gallus
XP_426719
319
34023
E68
P
V
S
P
Q
H
H
E
L
T
S
L
F
E
C
Frog
Xenopus laevis
Q9I8X5
313
34081
E68
Q
E
L
T
S
L
F
E
C
P
V
C
F
D
Y
Zebra Danio
Brachydanio rerio
Q7SYL3
331
34475
P77
A
L
P
V
A
A
L
P
G
Q
S
P
E
L
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P21461
314
33689
T68
A
G
M
S
A
D
L
T
S
L
F
E
C
P
V
Honey Bee
Apis mellifera
XP_394284
279
30558
L35
S
S
T
D
L
A
S
L
F
E
C
P
V
C
F
Nematode Worm
Caenorhab. elegans
Q965X6
339
37641
D78
S
A
G
G
G
A
T
D
D
S
S
A
E
I
L
Sea Urchin
Strong. purpuratus
XP_797311
281
31248
L37
T
N
Q
D
L
A
S
L
F
E
C
P
V
C
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9STN8
327
36556
P73
V
C
T
Y
S
M
Y
P
P
I
H
Q
C
H
N
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
70.6
N.A.
97.8
98.1
N.A.
56.5
91
85.8
76.1
N.A.
66.3
67.9
54.8
66.9
Protein Similarity:
100
N.A.
N.A.
78.4
N.A.
97.8
98.1
N.A.
63.9
93.5
88.2
82.4
N.A.
76.8
76.8
66.9
76.2
P-Site Identity:
100
N.A.
N.A.
0
N.A.
93.3
100
N.A.
6.6
0
0
26.6
N.A.
6.6
0
20
0
P-Site Similarity:
100
N.A.
N.A.
6.6
N.A.
93.3
100
N.A.
33.3
0
0
33.3
N.A.
26.6
6.6
26.6
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
30.2
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
47.7
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
8
8
24
16
39
0
0
8
0
0
8
0
0
8
% A
% Cys:
0
8
0
0
0
0
0
0
8
0
24
8
16
24
8
% C
% Asp:
0
0
0
24
8
8
0
8
8
0
0
0
8
8
0
% D
% Glu:
0
8
0
0
0
0
0
16
0
24
0
8
39
8
0
% E
% Phe:
0
0
0
0
0
0
8
0
24
0
8
0
16
0
24
% F
% Gly:
24
31
31
8
24
8
0
0
8
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
8
8
0
0
0
31
24
0
8
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
8
0
0
0
8
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
8
8
8
24
8
16
24
8
8
0
8
0
39
8
% L
% Met:
0
0
8
0
0
8
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
16
8
0
0
0
0
0
0
0
8
8
0
0
8
% N
% Pro:
8
8
8
8
0
24
0
16
31
8
0
31
0
8
0
% P
% Gln:
8
0
8
0
8
0
0
0
0
31
0
8
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
24
8
8
8
16
0
24
24
8
16
24
0
0
0
0
% S
% Thr:
8
0
16
8
8
0
16
16
0
8
0
0
0
0
31
% T
% Val:
16
8
0
8
0
0
24
0
0
0
8
0
24
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
8
0
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _