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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIAH2
All Species:
32.73
Human Site:
T254
Identified Species:
60
UniProt:
O43255
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43255
NP_005058.3
324
34615
T254
A
I
V
L
L
I
G
T
R
K
Q
A
E
N
F
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_863586
282
31108
R215
I
V
Q
L
I
G
T
R
K
Q
A
E
N
F
A
Cat
Felis silvestris
Mouse
Mus musculus
Q06986
325
34739
T255
A
I
V
L
L
I
G
T
R
K
Q
A
E
N
F
Rat
Rattus norvegicus
Q8R4T2
325
34681
T255
A
I
V
L
L
I
G
T
R
K
Q
A
E
N
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507643
433
47638
T365
A
I
V
Q
L
I
G
T
R
K
Q
A
E
N
F
Chicken
Gallus gallus
XP_426719
319
34023
T249
A
I
V
L
L
I
G
T
R
K
Q
A
E
N
F
Frog
Xenopus laevis
Q9I8X5
313
34081
K245
V
L
L
I
G
T
R
K
Q
A
E
N
Y
A
Y
Zebra Danio
Brachydanio rerio
Q7SYL3
331
34475
T263
A
I
V
L
L
I
G
T
R
K
Q
A
E
N
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P21461
314
33689
S246
A
I
V
Q
L
I
G
S
R
K
E
A
E
N
F
Honey Bee
Apis mellifera
XP_394284
279
30558
R212
I
V
Q
L
I
G
S
R
K
Q
A
E
N
F
A
Nematode Worm
Caenorhab. elegans
Q965X6
339
37641
S266
A
V
V
Q
L
I
G
S
K
K
E
A
D
N
F
Sea Urchin
Strong. purpuratus
XP_797311
281
31248
R214
I
V
Q
L
I
G
S
R
K
Q
A
E
N
F
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9STN8
327
36556
S255
Y
S
L
E
V
G
G
S
G
R
K
L
T
W
E
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
70.6
N.A.
97.8
98.1
N.A.
56.5
91
85.8
76.1
N.A.
66.3
67.9
54.8
66.9
Protein Similarity:
100
N.A.
N.A.
78.4
N.A.
97.8
98.1
N.A.
63.9
93.5
88.2
82.4
N.A.
76.8
76.8
66.9
76.2
P-Site Identity:
100
N.A.
N.A.
6.6
N.A.
100
100
N.A.
93.3
100
0
100
N.A.
80
6.6
60
6.6
P-Site Similarity:
100
N.A.
N.A.
33.3
N.A.
100
100
N.A.
93.3
100
40
100
N.A.
93.3
33.3
93.3
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
30.2
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
47.7
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
62
0
0
0
0
0
0
0
0
8
24
62
0
8
24
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% D
% Glu:
0
0
0
8
0
0
0
0
0
0
24
24
54
0
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
24
62
% F
% Gly:
0
0
0
0
8
31
70
0
8
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
24
54
0
8
24
62
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
8
31
62
8
0
0
0
0
% K
% Leu:
0
8
16
62
62
0
0
0
0
0
0
8
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
8
24
62
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
24
24
0
0
0
0
8
24
47
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
8
24
54
8
0
0
0
0
0
% R
% Ser:
0
8
0
0
0
0
16
24
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
8
8
47
0
0
0
0
8
0
0
% T
% Val:
8
31
62
0
8
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% W
% Tyr:
8
0
0
0
0
0
0
0
0
0
0
0
8
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _